ID A8BJU3_GIAIC Unreviewed; 536 AA.
AC A8BJU3;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=GH26 domain-containing protein {ECO:0000259|PROSITE:PS51764};
GN ORFNames=GL50803_10552 {ECO:0000313|EMBL:EDO78981.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO78981.1};
RN [1] {ECO:0000313|EMBL:EDO78981.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WB C6 {ECO:0000313|EMBL:EDO78981.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO78981.1}.
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DR EMBL; AACB02000021; EDO78981.1; -; Genomic_DNA.
DR RefSeq; XP_001706655.1; XM_001706603.1.
DR AlphaFoldDB; A8BJU3; -.
DR STRING; 184922.A8BJU3; -.
DR EnsemblProtists; EDO78981; EDO78981; GL50803_10552.
DR GeneID; 5699546; -.
DR KEGG; gla:GL50803_0010552; -.
DR VEuPathDB; GiardiaDB:GL50803_10552; -.
DR HOGENOM; CLU_508510_0_0_1; -.
DR OMA; EYCECAP; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00185; TNFRSF; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 1.
DR InterPro; IPR022790; GH26_dom.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS51764; GH26; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..536
FT /note="GH26 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002719714"
FT TRANSMEM 511..535
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 11..315
FT /note="GH26"
FT /evidence="ECO:0000259|PROSITE:PS51764"
SQ SEQUENCE 536 AA; 58171 MW; F72DB5558B3E0C65 CRC64;
MYSNIHVPML LSIAFVCVWL FHPVFAGAAV LGSVSGWFPI NETFDTELFL GKRLVFRALD
VAWTTTSATL KSVEDEINAI VSVNAIPVIN WNPLLSDTYR DTLQAIEDGL HDDIIDAFFT
LLNGTVQKSY CVLFFGTTCN SNGVYWSEDP ELYVRVYKRL HLKGKAAGVA DRIIWGWNID
ITKFKAVEGN PYALDTTNLV HTPSEYFPGE SYVNWIALQL INDDIHNWVD PREPIQVGMG
VASSLAPGKP VMLIGGTSSM VDDGHGEMVS STKAKSMWLE EFVETAHEHM DRTEGSAAVI
KTILLYNRES SLDTGFYNSV NGDVVTSISN SGVELFSYSV LETLFPDQVV AEPSSEPYID
EVSPIVAFGA ICGPGERGQA SSGTCAPCEA GTYSNKTAAS ECDPCPIGFY NEEVGQVECV
PCPPNKTTVH DGARLEEYCE CAPGFVLRDA DNIDAGCIQC QRNSYSKGGT STCQQCPSGN
RWPTGKSGVG CFCKKGTWDH KTEQCTTITS AFASSTSIAV SVCVGLALIL VTIVVN
//
