ID A8BLV7_GIAIC Unreviewed; 89 AA.
AC A8BLV7;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Ribosomal protein L37 {ECO:0000256|RuleBase:RU000576};
GN ORFNames=GL50803_0014171 {ECO:0000313|EMBL:KAE8302277.1},
GN GL50803_14171 {ECO:0000313|EMBL:EDO78515.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO78515.1};
RN [1] {ECO:0000313|EMBL:EDO78515.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO78515.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302277.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302277.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007829|PDB:7PWG, ECO:0007829|PDB:7PWO}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.75 ANGSTROMS).
RX PubMed=35100413; DOI=10.1093/nar/gkac046;
RA Hiregange D.G., Rivalta A., Bose T., Breiner-Goldstein E., Samiya S.,
RA Cimicata G., Kulakova L., Zimmerman E., Bashan A., Herzberg O., Yonath A.;
RT "Cryo-EM structure of the ancient eukaryotic ribosome from the human
RT parasite Giardia lamblia.";
RL Nucleic Acids Res. 50:1770-1782(2022).
RN [4] {ECO:0007829|PDB:8BR8, ECO:0007829|PDB:8BRM}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.25 ANGSTROMS), AND DISULFIDE BONDS.
RX PubMed=36912103; DOI=10.1093/nar/gkad176;
RA Majumdar S., Emmerich A., Krakovka S., Mandava C.S., Svard S.G., Sanyal S.;
RT "Insights into translocation mechanism and ribosome evolution from cryo-EM
RT structures of translocation intermediates of Giardia intestinalis. .";
RL Nucleic Acids Res. 51:3436-3451(2023).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000256|RuleBase:RU000576}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL37 family.
CC {ECO:0000256|ARBA:ARBA00009805, ECO:0000256|RuleBase:RU000576}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO78515.1}.
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DR EMBL; AACB02000025; EDO78515.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302277.1; -; Genomic_DNA.
DR RefSeq; XP_001706189.1; XM_001706137.1.
DR PDB; 7PWG; EM; 2.75 A; j=1-89.
DR PDB; 7PWO; EM; 2.75 A; j2=1-89.
DR PDB; 8BR8; EM; 3.35 A; Lk=1-89.
DR PDB; 8BRM; EM; 3.33 A; Lk=1-89.
DR PDB; 8BSI; EM; 3.40 A; Lk=1-89.
DR PDB; 8BSJ; EM; 6.49 A; Lk=1-89.
DR PDB; 8BTD; EM; 4.90 A; Lk=1-89.
DR PDB; 8BTR; EM; 3.25 A; Lk=1-89.
DR EMDB; EMD-13681; -.
DR EMDB; EMD-13683; -.
DR SMR; A8BLV7; -.
DR STRING; 184922.A8BLV7; -.
DR EnsemblProtists; EDO78515; EDO78515; GL50803_14171.
DR GeneID; 5699057; -.
DR KEGG; gla:GL50803_0014171; -.
DR VEuPathDB; GiardiaDB:GL50803_14171; -.
DR HOGENOM; CLU_150908_2_1_1; -.
DR OMA; RMAYLKH; -.
DR Proteomes; UP000001548; Chromosome 2.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 2.20.25.30; -; 1.
DR HAMAP; MF_00547; Ribosomal_L37e; 1.
DR InterPro; IPR001569; Ribosomal_eL37.
DR InterPro; IPR011331; Ribosomal_eL37/eL43.
DR InterPro; IPR018267; Ribosomal_eL37_CS.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR PANTHER; PTHR10768; 60S RIBOSOMAL PROTEIN L37; 1.
DR PANTHER; PTHR10768:SF0; RIBOSOMAL PROTEIN L37; 1.
DR Pfam; PF01907; Ribosomal_L37e; 1.
DR SUPFAM; SSF57829; Zn-binding ribosomal proteins; 1.
DR PROSITE; PS01077; RIBOSOMAL_L37E; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7PWG, ECO:0007829|PDB:7PWO};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000576};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Ribonucleoprotein {ECO:0000256|RuleBase:RU000576};
KW Ribosomal protein {ECO:0000256|RuleBase:RU000576,
KW ECO:0000313|EMBL:EDO78515.1}; RNA-binding {ECO:0000256|RuleBase:RU000576};
KW rRNA-binding {ECO:0000256|ARBA:ARBA00022730,
KW ECO:0000256|RuleBase:RU000576};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU000576};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DISULFID 19..37
FT /evidence="ECO:0007829|PDB:8BR8, ECO:0007829|PDB:8BRM"
FT DISULFID 19..34
FT /evidence="ECO:0007829|PDB:8BR8, ECO:0007829|PDB:8BRM"
FT DISULFID 22..37
FT /evidence="ECO:0007829|PDB:8BR8, ECO:0007829|PDB:8BRM"
FT DISULFID 34..37
FT /evidence="ECO:0007829|PDB:8BR8, ECO:0007829|PDB:8BRM"
SQ SEQUENCE 89 AA; 10301 MW; FEF8243B2B2A067D CRC64;
MSKGTASFGK RHTRIHGSCR RCGKHSFHLQ KHECASCGYP SAKMRRYNWS YKSLRRRTQG
TGSMSHMRKV YRAYNSGTLK ANARKYLAK
//
