ID A8BQB1_GIAIC Unreviewed; 203 AA.
AC A8BQB1;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Mitotic spindle checkpoint protein MAD2 {ECO:0000313|EMBL:EDO77944.1};
GN ORFNames=GL50803_00100955 {ECO:0000313|EMBL:KAE8304140.1},
GN GL50803_100955 {ECO:0000313|EMBL:EDO77944.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO77944.1};
RN [1] {ECO:0000313|EMBL:EDO77944.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO77944.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8304140.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8304140.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MAD2 family.
CC {ECO:0000256|ARBA:ARBA00010348}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO77944.1}.
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DR EMBL; AACB02000032; EDO77944.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8304140.1; -; Genomic_DNA.
DR RefSeq; XP_001705618.1; XM_001705566.1.
DR AlphaFoldDB; A8BQB1; -.
DR STRING; 184922.A8BQB1; -.
DR EnsemblProtists; EDO77944; EDO77944; GL50803_100955.
DR GeneID; 5698500; -.
DR KEGG; gla:GL50803_00100955; -.
DR VEuPathDB; GiardiaDB:GL50803_100955; -.
DR HOGENOM; CLU_072097_0_0_1; -.
DR InParanoid; A8BQB1; -.
DR OMA; VSEFFEY; -.
DR Proteomes; UP000001548; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IBA:GO_Central.
DR Gene3D; 3.30.900.10; HORMA domain; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR InterPro; IPR045091; Mad2-like.
DR PANTHER; PTHR11842; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2; 1.
DR PANTHER; PTHR11842:SF11; MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A; 1.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; The spindle assembly checkpoint protein mad2; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 12..194
FT /note="HORMA"
FT /evidence="ECO:0000259|PROSITE:PS50815"
SQ SEQUENCE 203 AA; 22545 MW; C8185F2473CD8674 CRC64;
MATQTKNAIT LRGSTAIVTE YFAYSINSIL YLRGIYGQDS FMSQQKYGLP LMVAKDPALS
KYLGEVLQRV AEWLMSGKVQ KLVMVLLPIG GSEPIEKWEF NVENEGVQAG ATSSKPEADV
QREIQAILRQ INASVSFLPV ISDPVTFDIM IYTDAAVPTP AEWEECPGRD HVHNAVEVKF
RDFSTKIHKV DTAVIYKSGE EAL
//
