ID A8BRX1_GIAIC Unreviewed; 373 AA.
AC A8BRX1;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=AstB/chuR-related protein {ECO:0000313|EMBL:EDO77546.1};
GN ORFNames=GL50803_0016519 {ECO:0000313|EMBL:KAE8304481.1},
GN GL50803_16519 {ECO:0000313|EMBL:EDO77546.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO77546.1};
RN [1] {ECO:0000313|EMBL:EDO77546.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO77546.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8304481.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8304481.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the radical SAM superfamily. Anaerobic
CC sulfatase-maturating enzyme family. {ECO:0000256|ARBA:ARBA00023601}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO77546.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACB02000038; EDO77546.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8304481.1; -; Genomic_DNA.
DR RefSeq; XP_001705220.1; XM_001705168.1.
DR AlphaFoldDB; A8BRX1; -.
DR STRING; 184922.A8BRX1; -.
DR EnsemblProtists; EDO77546; EDO77546; GL50803_16519.
DR GeneID; 5698096; -.
DR KEGG; gla:GL50803_0016519; -.
DR VEuPathDB; GiardiaDB:GL50803_16519; -.
DR HOGENOM; CLU_777602_0_0_1; -.
DR InParanoid; A8BRX1; -.
DR OMA; VHWQLNA; -.
DR Proteomes; UP000001548; Chromosome 4.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR023819; Pep-mod_rSAM_AF0577.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023867; Sulphatase_maturase_rSAM.
DR NCBIfam; TIGR04084; rSAM_AF0577; 1.
DR PANTHER; PTHR43273; ANAEROBIC SULFATASE-MATURATING ENZYME HOMOLOG ASLB-RELATED; 1.
DR PANTHER; PTHR43273:SF2; RADICAL SAM DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01067; SPASM/twitch_domain_containing; 1.
DR SFLD; SFLDG01104; Uncharacterised_Radical_SAM_Su; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 1..197
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 373 AA; 42225 MW; 5612626CF5D29BC9 CRC64;
MIYFVFCSAD CNLACSYCGN SPEDLCMPAK PTYEFEKLAE FIAGDDDPVF VFYGGEPLLN
RPYVCRVMDR FPDATFVLQS NCTLLYDLPT PYLKRFACIL LSIDGRPETV DAYRGEGVYE
RIEKNINDAR SRGYTGPIVA RMACSLKTDI YKDVHYLMYE SPLKFDAVYW QLDVEWDSPM
NARWGNFEVW MRQTYMPGVD RLFKEWREGL ERGDVKVIVP FNTITEAYLD CNAIDGADPS
VPRRGYLRCS AGHKAVSITT DGRVLACPVA SGECWNNLGK LSDSRTSLLG QKSVGGMCDV
CEVREVCGGR CLYANQTLWW GDDGHALVCE LNKHLIALCE SHSDRVQTML ATGKISWAQF
HFPSERYSLE IIP
//
