ID   A8BYS0_GIAIC            Unreviewed;       509 AA.
AC   A8BYS0;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=ATPase, AAA family {ECO:0000313|EMBL:EDO76451.1};
GN   ORFNames=GL50803_22138 {ECO:0000313|EMBL:EDO76451.1};
OS   Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO76451.1};
RN   [1] {ECO:0000313|EMBL:EDO76451.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WB C6 {ECO:0000313|EMBL:EDO76451.1};
RX   PubMed=17901334; DOI=10.1126/science.1143837;
RA   Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA   Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA   Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA   Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA   Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA   Svard S.G., Sogin M.L.;
RT   "Genomic minimalism in the early diverging intestinal parasite Giardia
RT   lamblia.";
RL   Science 317:1921-1926(2007).
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008959}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDO76451.1}.
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DR   EMBL; AACB02000067; EDO76451.1; -; Genomic_DNA.
DR   RefSeq; XP_001704125.1; XM_001704073.1.
DR   AlphaFoldDB; A8BYS0; -.
DR   STRING; 184922.A8BYS0; -.
DR   EnsemblProtists; EDO76451; EDO76451; GL50803_22138.
DR   GeneID; 5696987; -.
DR   KEGG; gla:GL50803_0022138; -.
DR   VEuPathDB; GiardiaDB:GL50803_22138; -.
DR   HOGENOM; CLU_017985_1_3_1; -.
DR   OMA; LTTMQTM; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   CDD; cd18139; HLD_clamp_RarA; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.20.272.10; -; 1.
DR   Gene3D; 1.10.3710.10; DNA polymerase III clamp loader subunits, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR021886; MgsA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13779:SF7; ATPASE WRNIP1; 1.
DR   PANTHER; PTHR13779; WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF12002; MgsA_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          135..259
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  54755 MW;  FF63F6BA9B0A8D72 CRC64;
     MLCCSSPSGS QESWSPEGQE QSSTGYLSKS LGQLPRPITR PATRAIPMDI APISQHPRCS
     MWNSQNPIKI LCPEIIITSA IGPASPPTSH RQEAMCLSMR LRPTTIDEII GNHHILSLTD
     GVISRIYEQS RTTHVLQSII ITGPPGTGKT SFARLYAKSF DPSYRLIEFK PGQATVAELN
     KVTERIYTDR ANSLTSARVC LFVDEAHRCT KAQQDRLLSA VEEGVLTLIL ATTSSPYTAI
     IEGLRSRCFL LSFNALTSKD ILQICVRGLN SMLDKLDTSV PLDICVEPSA IAKIVVAARG
     DGRKALSLLE LSVTGGRITE QGVALLLSGG AHGDAIMHCT LNQEQVKYEG VSGMIKAIRA
     SDPQGAIFYL AFLLRTAVDP LYIARRLIIS ASEDIGLADS QALSVAVSCY RATEVIGLPE
     AHYALAQTAL YLSLAPKSNS AGTALNNAFA AIDSATPTDC LPPEGYKSAS AGANYVYPHN
     YGGYVLESTL PESLRGQIFY SEASVHKPP
//