ID A8DVN5_NEMVE Unreviewed; 196 AA.
AC A8DVN5;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Sodium:proton antiporter {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g225760 {ECO:0000313|EMBL:EDO25724.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO25724.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO25724.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS478414; EDO25724.1; -; Genomic_DNA.
DR RefSeq; XP_001617824.1; XM_001617774.1.
DR AlphaFoldDB; A8DVN5; -.
DR EnsemblMetazoa; EDO25724; EDO25724; NEMVEDRAFT_v1g225760.
DR KEGG; nve:5496000; -.
DR HOGENOM; CLU_1264047_0_0_1; -.
DR InParanoid; A8DVN5; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR InterPro; IPR032813; Na_H_antiport_N.
DR PANTHER; PTHR37821; AMINO ACID TRANSPORTER YUIF-RELATED; 1.
DR PANTHER; PTHR37821:SF1; AMINO ACID TRANSPORTER YUIF-RELATED; 1.
DR Pfam; PF13726; Na_H_antiport_2; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..77
FT /note="Putative Na+/H+ antiporter N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13726"
FT DOMAIN 139..195
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
FT NON_TER 196
FT /evidence="ECO:0000313|EMBL:EDO25724.1"
SQ SEQUENCE 196 AA; 19949 MW; 0C22C9771F1B2431 CRC64;
MLILSLCRVH VVVALIVGAL AGGLLGGLGI EGSLAAFNKG LGGGATVALS YALLGAFAVA
IAKSGLAHAL ADKALAMVGK QDAKGAGLLK WLLIALLLVV AISSQNILPI HIAFIPLLVP
PLLYVLSKLQ LDRRLIACVL TFGLITPYMF LPVGFGGIFL NDILLANVAS GGVDTSSLDV
SKAMAIPALG MLFGLL
//
