ID A8DVU2_NEMVE Unreviewed; 284 AA.
AC A8DVU2;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g156779 {ECO:0000313|EMBL:EDO25667.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO25667.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO25667.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the patatin family.
CC {ECO:0000256|ARBA:ARBA00010240}.
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DR EMBL; DS478649; EDO25667.1; -; Genomic_DNA.
DR RefSeq; XP_001617767.1; XM_001617717.1.
DR AlphaFoldDB; A8DVU2; -.
DR STRING; 45351.A8DVU2; -.
DR EnsemblMetazoa; EDO25667; EDO25667; NEMVEDRAFT_v1g156779.
DR eggNOG; KOG0513; Eukaryota.
DR HOGENOM; CLU_000288_144_0_1; -.
DR InParanoid; A8DVU2; -.
DR OMA; ANNPAMC; -.
DR PhylomeDB; A8DVU2; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0047372; F:acylglycerol lipase activity; IBA:GO_Central.
DR GO; GO:0004620; F:phospholipase activity; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR PANTHER; PTHR32176:SF92; PATATIN-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR32176; XYLOSE ISOMERASE; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 8..206
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT NON_TER 284
FT /evidence="ECO:0000313|EMBL:EDO25667.1"
SQ SEQUENCE 284 AA; 31923 MW; 7CB36FD9A054019B CRC64;
MAKKIRILSL DGGGIRGIIS CVVLKYIQEQ LQKIDNPNAK IGDYFDLIAG SSTGGLLTAI
LLFPDNTNNA KFSIEAALDL YAKKGDTIFN VSFWEEIINP FGLFNEKISQ RNLERQLHEV
FGNLELRALI KPCLITSYDI NQRKAKFFCS HEANSSLENF YVKDVCRATS AAPTYFEPAK
IKSLYDQEFT LIDGGVYANN PALCAYAEAR KIPFSKILKD AEKVDYPDIN DMMIVSIGTG
EVLKPYTFEK FENAGKIKWI SPLIDILLSA NVETVNYHLS KMFE
//
