ID A8E4V7_XENTR Unreviewed; 676 AA.
AC A8E4V7; F6X037;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=TCDD-inducible poly [ADP-ribose] polymerase {ECO:0000313|RefSeq:NP_001106413.1};
DE EC=2.4.2.30 {ECO:0000313|RefSeq:NP_001106413.1};
DE SubName: Full=TCDD-inducible poly(ADP-ribose) polymerase {ECO:0000313|Ensembl:ENSXETP00000061824};
DE SubName: Full=Tiparp protein {ECO:0000313|EMBL:AAI53347.1};
GN Name=tiparp {ECO:0000313|EMBL:AAI53347.1,
GN ECO:0000313|Ensembl:ENSXETP00000061824,
GN ECO:0000313|RefSeq:NP_001106413.1,
GN ECO:0000313|Xenbase:XB-GENE-1000138};
GN Synonyms=parp-7 {ECO:0000313|RefSeq:NP_001106413.1}, parp7
GN {ECO:0000313|RefSeq:NP_001106413.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI53347.1};
RN [1] {ECO:0000313|RefSeq:NP_001106413.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI53347.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI53347.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000061824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000061824};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000061824}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001106413.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
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DR EMBL; BC153346; AAI53347.1; -; mRNA.
DR RefSeq; NP_001106413.1; NM_001112942.1.
DR PaxDb; 8364-ENSXETP00000061824; -.
DR Ensembl; ENSXETT00000065784; ENSXETP00000061824; ENSXETG00000012260.
DR GeneID; 100127576; -.
DR KEGG; xtr:100127576; -.
DR AGR; Xenbase:XB-GENE-1000138; -.
DR CTD; 25976; -.
DR Xenbase; XB-GENE-1000138; tiparp.
DR eggNOG; ENOG502QQXA; Eukaryota.
DR OMA; IEEANCR; -.
DR OrthoDB; 5490222at2759; -.
DR TreeFam; TF328965; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008143; Chromosome 5.
DR Bgee; ENSXETG00000012260; Expressed in heart and 14 other cell types or tissues.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd01439; TCCD_inducible_PARP_like; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR018123; WWE-dom_subgr.
DR InterPro; IPR037197; WWE_dom_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR45740; POLY [ADP-RIBOSE] POLYMERASE; 1.
DR PANTHER; PTHR45740:SF7; PROTEIN MONO-ADP-RIBOSYLTRANSFERASE TIPARP; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF02825; WWE; 1.
DR SMART; SM00678; WWE; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50918; WWE; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 2: Evidence at transcript level;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00723}.
FT DOMAIN 250..277
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 345..426
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 468..676
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT ZN_FING 250..277
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
SQ SEQUENCE 676 AA; 77421 MW; 05552C9B350BC987 CRC64;
MENSIQIMDT APHGECSVKV PCSDISGKDM SQRDFSMHSN KIPPLKPCFK KKQAPKLLDS
ETINALRPII TSFLGSGTLD EIFVSRNRAG NTSSLCEPID KKALGMEQQC PPTNSLISGS
PSLSPLTDQP PTVHAEQEDL VVHQPTVLDT TEPTFPSDNS NMTVNNNTAN GSFQDPLLQT
ISTDFTNPGC LDKITESYSS GLFQDNGSLD QYSLNQNNSN AGIFQDKTEE ASLLLVFELL
NQLQYHVHQK DGVDICVDFL QGLCLYGNDC QKHHTVLPYH WQVRRRATSI WQSVNDDSQE
HVERLYCSPD SDRIKMRYQG HDFLVDLNCM EIYESLEFDQ IRRLSTPTTS GVSSNYHTVW
KYFCRDHFGW REYSEPVVKL IEEANCRGLK EVRFVTWHNQ YILNIKDGFQ QNACFRKEIK
RRPLFRSSVI LLPHLQTLSG ISPVAPPANQ ADSLQILSPI AITSPNFYPE TWLSMDASQE
FFQVPMSKED KSYRTVYTLF HKTVPETRFR ILKIIRVQNL FLWEKYKRKK EFMTRKMTGL
DRIMNERHLF HGTSQDVVDA ICKHNFDPRV CGKHATMFGQ GSYFARKASY SHNFSKRSPK
GVHYMFLAKV LTGRYVVGNH TMRRPPPLNP GSLTSDLYDS CVDNFFEPQI FVIFNDDQSY
PYFIIQYEEV SNTVSI
//