ID A8FHC5_BACP2 Unreviewed; 584 AA.
AC A8FHC5;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=BPUM_2988 {ECO:0000313|EMBL:ABV63642.1};
OS Bacillus pumilus (strain SAFR-032).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=315750 {ECO:0000313|EMBL:ABV63642.1, ECO:0000313|Proteomes:UP000001355};
RN [1] {ECO:0000313|EMBL:ABV63642.1, ECO:0000313|Proteomes:UP000001355}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAFR-032 {ECO:0000313|EMBL:ABV63642.1,
RC ECO:0000313|Proteomes:UP000001355};
RX PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA Weinstock G.M.;
RT "Paradoxical DNA repair and peroxide resistance gene conservation in
RT Bacillus pumilus SAFR-032.";
RL PLoS ONE 2:E928-E928(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000813; ABV63642.1; -; Genomic_DNA.
DR RefSeq; WP_012011238.1; NZ_VEIS01000008.1.
DR AlphaFoldDB; A8FHC5; -.
DR STRING; 315750.BPUM_2988; -.
DR KEGG; bpu:BPUM_2988; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_89_26_9; -.
DR OrthoDB; 368131at2; -.
DR Proteomes; UP000001355; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43711:SF32; DRUG SENSORY PROTEIN A; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ABV63642.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 363..581
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 329..356
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 584 AA; 67973 MW; 8D1EAFA10F49C8AC CRC64;
MNLRAKLFFH FVGQMFIVIA VFIIGNTFSD NLYLKKYYEN MAETGLTKAD GDTLMSWLYF
NEDGEMEADD QLKQAVRKRD GWLQVIDSKK HNVYSYHRPK SIPTSYQKDE MIQIFEKRQF
KDYKMYFWPI EIDQKSFIVL YGFKTNSTKV ANYLKQNEKN LAALSQYSVE TKEFLKRMNG
SVHLFNDEGK YLKGIRANTN LKHDVTDVEL LKYQSKPWEF RSDLSYIRVN KNLYMIISVP
NKVYSPDGLY DKETDALNQY TTILIAGLAI TIIIVMTLWY SYRYGLPIYH IIRWLIFLSR
NKLQEPTNRK GIPISKNKKG RIKREYRLFE DILKTMDQLT LTLKENEENR RKIQTTREEW
IAGLSHDLKT PLSTIYGYGL MLESDQYQWS KEEVMEMGQV IREKSEYMST LIEDLNLTYR
LKNGALPINR KPVELGEFLA SIMDEFSRSS FSEDFSSSFE DQTNGVIFEI DKAWFRRVIE
NLLANAVKHN QKGTHITAVL SETNEEIRIE MKDNGCGMAQ ETVDHLFNRY YRGTNTNDPT
NGTGLGLAIA KELVLLHDGD IQVESEPGAG TTIAIILKKS PSVK
//
