ID A8GG37_SERP5 Unreviewed; 692 AA.
AC A8GG37;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN OrderedLocusNames=Spro_2976 {ECO:0000313|EMBL:ABV42077.1};
OS Serratia proteamaculans (strain 568).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=399741 {ECO:0000313|EMBL:ABV42077.1};
RN [1] {ECO:0000313|EMBL:ABV42077.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=568 {ECO:0000313|EMBL:ABV42077.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L.,
RA Vangronsveld J., van der Lelie D., Richardson P.;
RT "Complete sequence of chromosome of Serratia proteamaculans 568.";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
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DR EMBL; CP000826; ABV42077.1; -; Genomic_DNA.
DR AlphaFoldDB; A8GG37; -.
DR STRING; 399741.Spro_2976; -.
DR KEGG; spe:Spro_2976; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_6; -.
DR OrthoDB; 9759185at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:ABV42077.1};
KW Cilium {ECO:0000313|EMBL:ABV42077.1};
KW Flagellum {ECO:0000313|EMBL:ABV42077.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 117..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 210..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 692 AA; 75032 MW; 96281FCCF8E73314 CRC64;
MANLAALLRL PGSFKDTQWQ VLAGPILILM ILSMMVLPLP AFILDLLFTF NIALSIMVLL
VAMFTQRTLE FAAFPTILLF STLLRLSLNV ASTRIILMEG HTGSAAAGRV VEAFGHFLVG
GNFAIGIVVF IILVLINFMV ITKGAGRIAE VGARFVLDGM PGKQMAIDAD LNAGLIGEEE
AKKRRSEVTQ EADFYGSMDG ASKFVRGDAV AGLMIMILNV VGGLLVGVIQ HGMEVGTAAE
TYTLLTIGDG LVAQIPALVI STAAGVIVTR VATDQDVGEQ MVGQLFNNPR VMLLSAAVLG
LLGMVPGMPN LVFLLFTAAL LGLAWWLRGR DQQAPKEQEA PITQDNPQAV EASWSDVQLE
DPLGMEVGYR LIPMVDFQQN GELLGRIRGI RKKFAQEMGY LPPVVHIRDN LELPPASYRI
LMKGVEIGSG EAQPGRWLAI NPGNAVGELA GDKTTDPAFG LEAVWIDSAL REQAQIQGFT
VVEASTVVAT HLNHLIGQFA SELFGRQETQ QLLDRVAQDM PKLTEDFVPG VVTLTTLHKV
LQNLLTERVS IRDMRTIIET LAEHAPTQTD PYELTTVVRV ALGRAITQQW FPGNGEIQVI
GLDTQLERLL LQALQGGGGL EPGLADRLLD QAKQALQRQE MLSAPPVLLV NHALRALLAR
FLRRSLPQLV VLSNLEINDD RQIRMTSTIG VA
//
