ID A8H212_SHEPA Unreviewed; 1353 AA.
AC A8H212;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Spea_1272 {ECO:0000313|EMBL:ABV86599.1};
OS Shewanella pealeana (strain ATCC 700345 / ANG-SQ1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=398579 {ECO:0000313|EMBL:ABV86599.1, ECO:0000313|Proteomes:UP000002608};
RN [1] {ECO:0000313|EMBL:ABV86599.1, ECO:0000313|Proteomes:UP000002608}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700345 / ANG-SQ1 {ECO:0000313|Proteomes:UP000002608};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C.,
RA Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E.,
RA Zhao J.-S.Z., Manno D., Hawari J., Richardson P.;
RT "Complete sequence of Shewanella pealeana ATCC 700345.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000851; ABV86599.1; -; Genomic_DNA.
DR RefSeq; WP_012154525.1; NC_009901.1.
DR STRING; 398579.Spea_1272; -.
DR REBASE; 16545; Spe345ORF1272P.
DR KEGG; spl:Spea_1272; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_004385_0_0_6; -.
DR OrthoDB; 9782445at2; -.
DR Proteomes; UP000002608; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002608};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 566..687
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 869..973
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 1025..1204
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
FT REGION 1316..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1316..1333
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 152250 MW; 0890F52D7EAFA9C8 CRC64;
MATKSEEFFH DKWLGHVQTE SDGLVVAKPV LLAANCAQRQ SPNTQDKLRE LCPHGPEEQP
RRISDLLQFF YQLLDFDADL FDTAVEIQDE VSLYAPEGPQ TVRPTLGLLR QDELRQRDGA
GSPASNAAEK YVALIWDITD IDGETNEEAV GLTLDKPEII TGEWPYSAAA KFDRLLRHCQ
VPVGILTNRE VIRLVYAPHG ESSGYITFRI DDMATVGGRP ILDAMIMLLC ANQWFGVSDE
NSLPSLLRRS REYQGTVTED LAEQVFSGLE QLLNGFQTAA ERDKSGLLLE ALERDEDHLY
RGLLTVMLRM VFILFAEDRS LLPVEHPLYA KRMSLLGLFE RLQRDHGNFP DSMSNRFGAW
GHIISLSRTI YLGVDHGDFH IPARQGDLFD PHRYAFLEGW TGDSSPVITH TARSEVQVPT
VDDGTVFALL QSLLIFQGQR LSYRTLDVEQ IGSVYEALMG YHVYQSESPA VAIKLNSKKG
AAKYWLEASA VLARPAGQRI KWLQSECGFD KPVATQIKKV LGDAEKTIAE NPNAVIESLL
ALAAGKKENR YEQLARAGQY ILQPGTERRR SGSHYTPRSL TAPIVSKTLQ PLLRCLGETP
SAEQILELKI CDPAMGSGAF LVECCRQLAD EVVAAWGRTQ EIENIAVNCP EGDVVAHARR
LVAQCCLYGV DKNIMAVQLA KLSLWLFTLA RELPFTFLDH NLRYGDSLVG LNFEQIKAFH
WKPTQQLSFL EDEITRTLDE VVSIRQEIHQ LAKNSTPEGQ WLKAQRLFDA NDATEKVRKI
ADVCVGAFFA EDKIKARLNE RQVREGVIRA WLEGDEESKL RVNQWSKDIR DLHAPFHWWV
EFPEVFYEER SDPLASDQGK LVAYMDGFVG NPPFLGGRRI SENYGTEYSN WISGEHSGSM
NADLSAYFFR RSAQLSGTHG VVGLIATNTI GQGDTRLTGL AAMLADDWVI TDAINSMAWP
GSAAVTVSVV HAVHGSLKKY RGCQLDGVDC QAINSRLRPK PERDDPRPLK ANSGQSFQGH
ILLGTGFTLS QKERDDICIS SPLSTTRILP FLGGAEVNSS PTQDFDRYVI DFESIPLESA
EKTPELLERV RLLVKPERDK QKRKHLRERW WQFAENRPAM RAALNPLDRC LVTARVTKHL
CFSFQPTDRV FNEKLYIFPM DTFTAFAVLQ SRIHECWTWL LSSTLETRLN YSASECFITF
PFPQVKPSSC IEELEQRGSA LYSARAKFMV DSDEGLTKTY NALKDPECDN ECILNLRRLH
ETMDRAVVDA YGWSDIEVPP YCPMNADDEA ALEAFNDEII DRLYVLNAER AAAEERQELI
DKPPKKKAVN KSASIKADKL PNSSLNLFDQ NNE
//
