ID A8HT69_CHLRE Unreviewed; 1042 AA.
AC A8HT69;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=CHLRE_13g575950v5 {ECO:0000313|EMBL:PNW73865.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055 {ECO:0000313|EMBL:PNW73865.1, ECO:0000313|Proteomes:UP000006906};
RN [1] {ECO:0000313|EMBL:PNW73865.1, ECO:0000313|Proteomes:UP000006906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503 {ECO:0000313|Proteomes:UP000006906};
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM008974; PNW73865.1; -; Genomic_DNA.
DR RefSeq; XP_001693528.1; XM_001693476.1.
DR AlphaFoldDB; A8HT69; -.
DR STRING; 3055.A8HT69; -.
DR PaxDb; 3055-EDP08782; -.
DR EnsemblPlants; PNW73865; PNW73865; CHLRE_13g575950v5.
DR GeneID; 5719232; -.
DR Gramene; PNW73865; PNW73865; CHLRE_13g575950v5.
DR KEGG; cre:CHLRE_13g575950v5; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_004372_3_0_1; -.
DR InParanoid; A8HT69; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 5478541at2759; -.
DR Proteomes; UP000006906; Chromosome 13.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000006906};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|RuleBase:RU364014}.
FT DOMAIN 689..903
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
SQ SEQUENCE 1042 AA; 105512 MW; 71B924FF22766ADF CRC64;
MPFFDKPEWI QHAGGVSIMG VDLDPSGVRM ATCGSDNRIR IWAMRPVLSE VAEQDPAVPK
QLAVLCDALT PINAIRFAPS SQLLAAGTDD SEGLVYELRE GRGSAVFGSG ESANIENWRL
RIKLRGHASN VLDVAWAPDS RRLATCSVDN KVKVWDTTNG HCLRTLEGHV GHVKGVAWDP
FDFFLASQGD REAIVWRLED GSQVAIIREP FEKAPIVSFG LRPGWSPDGQ TLALPNGYDK
GMHTVPLIKR NSWVPGEFCL VGHKGPVTAI RYNPHLYTPA HKPGAAPTSP DDEAAGSIIT
AGSTDKTFSI WAPCAGDEPL AVARGFFGGM VNDVAWSADG RVMVVAAYDG SVATALFADG
ELGKRVPQAE VEALLAQLYG DPALRAGAAG REGGGGMGLG GRGGHSGLAA APELMALEAR
ARAEVEREER LNSRLRADGA AAAAAGAGAV VGAGTSGAAG PAAAGAAGLR PPLGAATGLA
RAAMPPTAPA AARVPLAVTQ NGVGSAGRGA GVGSNSPAKA GAGGARGGPA GTSGRDADQP
PAKRIAVQPV GSAATAMGAR AGAATAATTA TAPPGVAAGA GAGAGGHGAG GGSAAASPVL
VPVEALHAHF SFLIHAQPGS TGEGQVELQA LNTGRDARGR PAGELLCLVG GQRCWGDSVQ
GAVVALAGSS RLAAAATSNG DLMIYSSAGR RLFPPIRLGW PAAFLTVAPG SSLLLALLTD
GSLKLWDFGA GECLLESSVA PLLLPPGAGV PGLAAAVAAA QPPVLKVTAV RITASGAPLV
VLSNAHAYVH HGGLRTWVRV ADDAFPASAF TTNLTSAATG ELSKLQAAVA QRRHPADVMT
TSALHAARPA AAARSEQAVL EHNLASAAAL QSPAEWRLWL ITYVRRLAAD EDESRLRDLI
SELLGPLRWT PATHAAAAAG SSRAGGANAP AAAAAAAATS SSWEPALGSS VSGGRWAPVF
LGFDKRRLLR EVVLKEVARN RSYQQLVAEV LEQLKQVDAA AAAAAAVQQP HARGQADGVN
APAGDGAAAP AGAASSQPMV MG
//
