ID A8IFJ5_AZOC5 Unreviewed; 170 AA.
AC A8IFJ5;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=thioredoxin-dependent peroxiredoxin {ECO:0000256|ARBA:ARBA00013017};
DE EC=1.11.1.24 {ECO:0000256|ARBA:ARBA00013017};
DE AltName: Full=Bacterioferritin comigratory protein {ECO:0000256|ARBA:ARBA00041373};
DE AltName: Full=Thioredoxin peroxidase {ECO:0000256|ARBA:ARBA00032824};
DE AltName: Full=Thioredoxin-dependent peroxiredoxin Bcp {ECO:0000256|ARBA:ARBA00042639};
GN OrderedLocusNames=AZC_3622 {ECO:0000313|EMBL:BAF89620.1};
OS Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG
OS 6465 / NBRC 14845 / NCIMB 13405 / ORS 571).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Xanthobacteraceae; Azorhizobium.
OX NCBI_TaxID=438753 {ECO:0000313|EMBL:BAF89620.1, ECO:0000313|Proteomes:UP000000270};
RN [1] {ECO:0000313|EMBL:BAF89620.1, ECO:0000313|Proteomes:UP000000270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 /
RC NCIMB 13405 / ORS 571 {ECO:0000313|Proteomes:UP000000270};
RX PubMed=17720818; DOI=10.1128/AEM.01514-07;
RA Suzuki S., Aono T., Lee KB., Suzuki T., Liu CT., Miwa H., Wakao S., Iki T.,
RA Oyaizu H.;
RT "Rhizobial factors required for stem nodule maturation and maintenance in
RT Sesbania rostrata-Azorhizobium caulinodans ORS571 symbiosis.";
RL Appl. Environ. Microbiol. 73:6650-6659(2007).
RN [2] {ECO:0000313|Proteomes:UP000000270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 /
RC NCIMB 13405 / ORS 571 {ECO:0000313|Proteomes:UP000000270};
RA Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T.,
RA Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B.,
RA Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
RT "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium
RT caulinodans ORS571.";
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:BAF89620.1, ECO:0000313|Proteomes:UP000000270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 /
RC NCIMB 13405 / ORS 571 {ECO:0000313|Proteomes:UP000000270};
RX PubMed=18522759; DOI=10.1186/1471-2164-9-271;
RA Lee KB., Backer P.D., Aono T., Liu CT., Suzuki S., Suzuki T., Kaneko T.,
RA Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B.,
RA Binnewies T.T., Ussery D.W., D'Haeze W., Herder J.D., Gevers D.,
RA Vereecke D., Holsters M., Oyaizu H.;
RT "The genome of the versatile nitrogen fixer Azorhizobium caulinodans
RT ORS571.";
RL BMC Genomics 9:271-271(2008).
RN [4] {ECO:0000313|EMBL:BAF89620.1, ECO:0000313|Proteomes:UP000000270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 /
RC NCIMB 13405 / ORS 571 {ECO:0000313|Proteomes:UP000000270};
RX PubMed=19542345; DOI=10.1128/AEM.00398-09;
RA Tsukada S., Aono T., Akiba N., Lee KB., Liu CT., Toyazaki H., Oyaizu H.;
RT "Comparative genome-wide transcriptional profiling of Azorhizobium
RT caulinodans ORS571 grown under free-living and symbiotic conditions.";
RL Appl. Environ. Microbiol. 75:5037-5046(2009).
RN [5] {ECO:0000313|EMBL:BAF89620.1, ECO:0000313|Proteomes:UP000000270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 /
RC NCIMB 13405 / ORS 571 {ECO:0000313|Proteomes:UP000000270};
RX PubMed=20382809; DOI=10.1128/AEM.00238-10;
RA Akiba N., Aono T., Toyazaki H., Sato S., Oyaizu H.;
RT "phrR-like gene praR of Azorhizobium caulinodans ORS571 is essential for
RT symbiosis with Sesbania rostrata and is involved in expression of reb
RT genes.";
RL Appl. Environ. Microbiol. 76:3475-3485(2010).
RN [6] {ECO:0000313|EMBL:BAF89620.1, ECO:0000313|Proteomes:UP000000270}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 /
RC NCIMB 13405 / ORS 571 {ECO:0000313|Proteomes:UP000000270};
RX PubMed=21571889; DOI=10.1128/AEM.02327-10;
RA Liu CT., Lee KB., Wang YS., Peng MH., Lee KT., Suzuki S., Suzuki T.,
RA Oyaizu H.;
RT "Involvement of the azorhizobial chromosome partition gene (parA) in the
RT onset of bacteroid differentiation during Sesbania rostrata stem nodule
RT development.";
RL Appl. Environ. Microbiol. 77:4371-4382(2011).
CC -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC respectively. Plays a role in cell protection against oxidative stress
CC by detoxifying peroxides and as sensor of hydrogen peroxide-mediated
CC signaling events. {ECO:0000256|ARBA:ARBA00003330}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-
CC disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-
CC COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924,
CC ChEBI:CHEBI:50058; EC=1.11.1.24;
CC Evidence={ECO:0000256|ARBA:ARBA00000280};
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SIMILARITY: Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.
CC {ECO:0000256|ARBA:ARBA00038489}.
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DR EMBL; AP009384; BAF89620.1; -; Genomic_DNA.
DR AlphaFoldDB; A8IFJ5; -.
DR STRING; 438753.AZC_3622; -.
DR KEGG; azc:AZC_3622; -.
DR eggNOG; COG1225; Bacteria.
DR HOGENOM; CLU_042529_14_1_5; -.
DR Proteomes; UP000000270; Chromosome.
DR GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd03017; PRX_BCP; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR000866; AhpC/TSA.
DR InterPro; IPR024706; Peroxiredoxin_AhpC-typ.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR42801:SF24; PEROXIREDOXIN BCP; 1.
DR PANTHER; PTHR42801; THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE; 1.
DR Pfam; PF00578; AhpC-TSA; 1.
DR PIRSF; PIRSF000239; AHPC; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000270}.
FT DOMAIN 18..170
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT ACT_SITE 60
FT /note="Cysteine sulfenic acid (-SOH) intermediate; for
FT peroxidase activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000239-1"
SQ SEQUENCE 170 AA; 18337 MW; A3931EDD69F605A1 CRC64;
MRLYDVVTSK GRQMSQIPAI GTPAPAFTLP RDGGGEVSLK DFAGRKLVLY FYPKADTPGC
TKEAIAFNGL RAEFAAADTA ILGVSADAVK AQDKFKTKYT LEFPLGSDET HAMLEAYGVW
AEKSMYGKTY MGVSRATLLI GRDGKVAQVW PKVKVDGHAE DVLKAAQALD
//
