ID A8JQV8_DROME Unreviewed; 1446 AA.
AC A8JQV8;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 24-JAN-2024, entry version 128.
DE SubName: Full=Polychaetoid, isoform K {ECO:0000313|EMBL:ABW08623.1};
GN Name=pyd {ECO:0000313|EMBL:ABW08623.1,
GN ECO:0000313|FlyBase:FBgn0262614};
GN Synonyms=CG11782 {ECO:0000313|EMBL:ABW08623.1}, CG11962
GN {ECO:0000313|EMBL:ABW08623.1}, CG12409 {ECO:0000313|EMBL:ABW08623.1},
GN CG31349 {ECO:0000313|EMBL:ABW08623.1}, CG9729
GN {ECO:0000313|EMBL:ABW08623.1}, CG9731 {ECO:0000313|EMBL:ABW08623.1},
GN CG9763 {ECO:0000313|EMBL:ABW08623.1}, CT36877
GN {ECO:0000313|EMBL:ABW08623.1}, Dmel\CG43140
GN {ECO:0000313|EMBL:ABW08623.1}, DZO-1 {ECO:0000313|EMBL:ABW08623.1},
GN dzo-1 {ECO:0000313|EMBL:ABW08623.1}, Pch
GN {ECO:0000313|EMBL:ABW08623.1}, Pyd {ECO:0000313|EMBL:ABW08623.1},
GN pyd(Z01) {ECO:0000313|EMBL:ABW08623.1}, Pyd/ZO-1
GN {ECO:0000313|EMBL:ABW08623.1}, tam {ECO:0000313|EMBL:ABW08623.1},
GN Tamou {ECO:0000313|EMBL:ABW08623.1}, xvt
GN {ECO:0000313|EMBL:ABW08623.1}, ZO-1 {ECO:0000313|EMBL:ABW08623.1}, ZO1
GN {ECO:0000313|EMBL:ABW08623.1};
GN ORFNames=CG43140 {ECO:0000313|EMBL:ABW08623.1,
GN ECO:0000313|FlyBase:FBgn0262614}, Dmel_CG43140
GN {ECO:0000313|EMBL:ABW08623.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:ABW08623.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC {ECO:0000256|ARBA:ARBA00004435}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AE014297; ABW08623.1; -; Genomic_DNA.
DR RefSeq; NP_001097712.1; NM_001104242.3.
DR SMR; A8JQV8; -.
DR IntAct; A8JQV8; 1.
DR EnsemblMetazoa; FBtr0305302; FBpp0293845; FBgn0262614.
DR GeneID; 41062; -.
DR UCSC; CG31349-RH; d. melanogaster.
DR AGR; FB:FBgn0262614; -.
DR CTD; 41062; -.
DR FlyBase; FBgn0262614; pyd.
DR VEuPathDB; VectorBase:FBgn0262614; -.
DR GeneTree; ENSGT00940000171028; -.
DR OrthoDB; 2904077at2759; -.
DR BioGRID-ORCS; 41062; 0 hits in 3 CRISPR screens.
DR ChiTaRS; pyd; fly.
DR GenomeRNAi; 41062; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0262614; Expressed in wing disc and 62 other cell types or tissues.
DR ExpressionAtlas; A8JQV8; baseline and differential.
DR Genevisible; A8JQV8; DM.
DR GO; GO:0005912; C:adherens junction; IDA:FlyBase.
DR GO; GO:0045177; C:apical part of cell; IDA:FlyBase.
DR GO; GO:0030424; C:axon; IDA:FlyBase.
DR GO; GO:0016323; C:basolateral plasma membrane; IDA:FlyBase.
DR GO; GO:0005923; C:bicellular tight junction; IBA:GO_Central.
DR GO; GO:0005917; C:nephrocyte diaphragm; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IDA:FlyBase.
DR GO; GO:0050839; F:cell adhesion molecule binding; IPI:FlyBase.
DR GO; GO:0035147; P:branch fusion, open tracheal system; IMP:FlyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IMP:FlyBase.
DR GO; GO:0045216; P:cell-cell junction organization; IBA:GO_Central.
DR GO; GO:0022416; P:chaeta development; IMP:FlyBase.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0007391; P:dorsal closure; IMP:FlyBase.
DR GO; GO:0035156; P:fusion cell fate specification; IMP:FlyBase.
DR GO; GO:0008258; P:head involution; IMP:FlyBase.
DR GO; GO:0036059; P:nephrocyte diaphragm assembly; IMP:FlyBase.
DR GO; GO:0007424; P:open tracheal system development; IMP:FlyBase.
DR GO; GO:0150105; P:protein localization to cell-cell junction; IBA:GO_Central.
DR GO; GO:0030155; P:regulation of cell adhesion; IMP:FlyBase.
DR GO; GO:0016476; P:regulation of embryonic cell shape; IMP:FlyBase.
DR GO; GO:0035220; P:wing disc development; IMP:FlyBase.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd11859; SH3_ZO; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR13865:SF28; POLYCHAETOID, ISOFORM O; 1.
DR PANTHER; PTHR13865; TIGHT JUNCTION PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
PE 1: Evidence at protein level;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A8JQV8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 306..393
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 454..536
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 696..769
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 959..1060
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 12..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1405..1446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..175
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1335..1353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1446 AA; 159531 MW; C10DA791CFC3D0AF CRC64;
MSQFDYACYT VPECSTDDDD DNDDELGSNV TLENKDHSDC TLESDATTTT SSLERHMYRN
RYRSNRSFGP QRVSMPILRS SRSREMTPQL GMYHEGPNRD PQWGYFVPLS PNFFFSPPMQ
RRRYREKEND RNRRAVSYGG DATSSPHSAT IPRAAPRRVA LMKDPPPPPP PKPQLGSKAD
SVSHLASKYP QSEYNLIQKI DSNSTLTAPA QYQPQNFYAN TGTISSTNGY GSLLCHASST
TSPLAVRKRD KLLHRFSDAA TLGRKLKKKK NTNRTCRSMT EAIEMLADPV IEDEFFGDRT
TWEYHTVAVT RVPGYGFGIA VSGGRDNPHF ANGDPSIAVS DVLKGGPAED RLQVNDRIIS
VNGVSLENVE YATAVQVLRD SGNTVQLVVK RRVPLNPINA AGAVQHQHSH SLSSVGLMAN
GSGGVAPTPI TSLSQPNSLN SSLVQNASSG QPIKVTLTKG GKKDDYGVVL GCRLFVKEIS
SKAREQLNAN GYSLQEGDII TRIHNTNCGD TMSLKEAKKI IDGCKERLNL VVLRDITNQT
AVSQLNLNNS ASHQASGNIY ATHQPQVSGC SSSNNNLEDP YLPGGASYSS QNLYVQPPTR
TSNGPNINGN GLNDEKSNLT PRGRSRGPIM DGVSLQQLDR PVTPTRGRSA AIDEPPRPPP
PRGSSGGAAQ EDFYSSRRQL YEERQSAEPR FISFQKEGSV GIRLTGGNEA GIFVTAVQPG
SPASLQGLMP GDKILKVNDM DMNGVTREEA VLFLLSLQDR IDLIVQYCKE EYDEVVTNQR
GDSFHIKTHF HCDNPSKGEM AFKAGDVFRV IDTLHNGVVG SWQVLKIGRG HQEMQRGVIP
NKSRAEELAT AQFNATKKEM NANESRGNFF RRRRSTHRRS KSLSRENWDD VVFSDSISKF
PAYERVVLRH PGFVRPVVLF GPVSDLARER LAKDFPDKFS TPLQDDDKSA ATSGKCRIVR
LSNIRDVMDR GKHALLDITP NAVDRLNYAQ FYPVVIFLKT DSKHVIKQLR HGLPKAAHKS
SKKLLEQCQK LERVWSHIFS TQIALSDEES WYRKLRDSID LQQSGAVWMS ESKFPDSPTE
MLFPPYIAQP CKLACCRPIS STSVPRYSQD MNLNLNQNPS KSYSLIQNQA HTPPPPRPPP
VGYAHSQSLA EKPRDRRSYT MVPIIKPASS MPSGLAPTVE PAAPMMPLDD CVLAMDGSNS
QYHSSQPNLM SQSYLNSNLN GGSTSAVDQT NHSNAMRGFQ PGPSVVSRYG LRSNAQVERR
TTPYYYHELL LQKNLFDSSL NLLPQQQQQH QPDLAKSKNS NVQLEQQQQQ QQQHQKHLAD
ASNASKRAPM AKPQQRLISN GQGRSNYSSS GSLSNLLGNG HGLSNGHESS DGTLVDEGSF
TLAFNNLTNQ IASLNNSSSL NNNNCSTSRS INNNSNSHNI NANNNNSHVN NADSNNNVGQ
SNECIA
//
