ID A8JUV3_DROME Unreviewed; 1457 AA.
AC A8JUV3;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=NFAT nuclear factor, isoform B {ECO:0000313|EMBL:ABW09408.1};
GN Name=NFAT {ECO:0000313|EMBL:ABW09408.1,
GN ECO:0000313|FlyBase:FBgn0030505};
GN Synonyms=Dmel\CG11172 {ECO:0000313|EMBL:ABW09408.1}, dNFAT
GN {ECO:0000313|EMBL:ABW09408.1}, EP1335 {ECO:0000313|EMBL:ABW09408.1},
GN MESR1 {ECO:0000313|EMBL:ABW09408.1}, NF-AT5
GN {ECO:0000313|EMBL:ABW09408.1}, Nfat {ECO:0000313|EMBL:ABW09408.1},
GN NFAT5 {ECO:0000313|EMBL:ABW09408.1};
GN ORFNames=CG11172 {ECO:0000313|EMBL:ABW09408.1,
GN ECO:0000313|FlyBase:FBgn0030505}, Dmel_CG11172
GN {ECO:0000313|EMBL:ABW09408.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:ABW09408.1, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE014298; ABW09408.1; -; Genomic_DNA.
DR RefSeq; NP_001096974.1; NM_001103504.2.
DR AlphaFoldDB; A8JUV3; -.
DR SMR; A8JUV3; -.
DR IntAct; A8JUV3; 5.
DR STRING; 7227.FBpp0111893; -.
DR PaxDb; 7227-FBpp0111893; -.
DR DNASU; 32321; -.
DR EnsemblMetazoa; FBtr0112980; FBpp0111893; FBgn0030505.
DR GeneID; 32321; -.
DR KEGG; dme:Dmel_CG11172; -.
DR UCSC; CG11172-RB; d. melanogaster.
DR AGR; FB:FBgn0030505; -.
DR CTD; 32321; -.
DR FlyBase; FBgn0030505; NFAT.
DR VEuPathDB; VectorBase:FBgn0030505; -.
DR eggNOG; ENOG502QSVE; Eukaryota.
DR GeneTree; ENSGT00940000155213; -.
DR InParanoid; A8JUV3; -.
DR OMA; NAAMQYH; -.
DR OrthoDB; 5405363at2759; -.
DR PhylomeDB; A8JUV3; -.
DR Reactome; R-DME-2025928; Calcineurin activates NFAT.
DR Reactome; R-DME-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-DME-4086398; Ca2+ pathway.
DR Reactome; R-DME-5607763; CLEC7A (Dectin-1) induces NFAT activation.
DR BioGRID-ORCS; 32321; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 32321; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0030505; Expressed in saliva-secreting gland and 28 other cell types or tissues.
DR ExpressionAtlas; A8JUV3; baseline and differential.
DR Genevisible; A8JUV3; DM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:2000301; P:negative regulation of synaptic vesicle exocytosis; IDA:FlyBase.
DR GO; GO:0010604; P:positive regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051173; P:positive regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009651; P:response to salt stress; IMP:FlyBase.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd07882; RHD-n_TonEBP; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR015646; NFAT5_RHD_DNA-bd.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF7; NFAT NUCLEAR FACTOR, ISOFORM B; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803}.
FT DOMAIN 486..668
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 20..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 816..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1325..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 983..1018
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 380..394
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 816..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1344
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1457 AA; 155805 MW; FBBAACB5F497DB96 CRC64;
MRFTYNQYKH YESGYRIPSK MHNLSHNNNN NSNNNNNGGG HTNNNNNGNN SGHHYAHHNN
SNNGGNNNTN FQAYQHHYKS NFGMRMTMST NSTMSARIHR KGFRIPSKRQ PGKGLPGKLH
TITRTGPGKM VPGKRIPQRP HPPPCDNSND SGLGFDQHTE LRSSAGAGGV TDPAANGGSG
SNSGQRSSLL VNSALTNTVA AAAAAAAAAV ASNTLQQHQQ HHQQQQQQQQ QQQQQQQQQQ
QQQQQQQHSP QQHLIRAIPV SRSRNNTKVM AHCLEDLDLI SASSEDSSTI ATPAGLDEDT
GFVNDTKTTT TGGNSSSDPF GGVFQATEAA VAAAVNAFNL QQQQHSVQQQ QHQLFQYNGL
LLQPQQQLQQ QQSHHQQQQQ QQQHHRHGKH IKRKKLECNQ VELDNDDACS EDEFIRKIAS
SVTMSPTLEA TPSPPPIVAS VAPATTIVSL LPLISSGNSN NNNNNNNIET KFISARNVTR
VANKRQPTTP LNSVASSNDG QVQLEILSQP EQQHRARYQT EGSRGAVKDR SGNGFPIVRL
TGYDKVAVLQ VFIGTDIGRV APHMFYQACK VAGKNSTQCN EKKVDGTMVI EIDFKPETDM
TITCDCVGIL KERNVDVEHR FPEHLAQKNK KKSTRCRMVF RTQLTRDDGT TETLQVCSNP
IICTQPPGVP EICKKSLNSC PVDGGLELFI IGKNFLKDTH VVFQETYDSV NGDDPATEIA
VRQQLIGGTA ALWEQSVLPD KEYLHQTHLI CTVPPYLHQN ILKPVQVQVS IVSSGKKSEP
HTFTYTAKGQ YTTLAAASTL SNTIHAQDVS GFMDTTSASN ASGSSGWSAA GGSGNNTSTG
DNVEAKHEID SGMMPPPITT QIPMGVRRSS LPSVTPMITD QQLVHLNAVA ASAEALKTEL
DDSNSHSPLT GESTPDSPNA ALQYHRFARK PSLDTIMYDQ SNSLPGFPTV VAPATAAAVA
AAVDIDPTAV AVAVELAVKN EIVKHVVQQH QQMQEQMHEQ QQQQQQQQQQ QQQQQQQQPQ
QQQQQQVHKF IDELTKSTSV VSSNGTTEPA LFTTSAVIDH ALTDILQAKV GIAPPNVVLE
RSLSLSSTNS SSSMSGSESS PNSSPLTQDI ILNSEPAAAL AGAAALGGPA PVDVTGGLST
DIIMNPAVSP STILCSANGA ATAVVPNILA PHQVTMANSI LNDIAMQPEP TQQDAAVAAL
ALSNIMMSPP TAASGVGVGD TLPPTPATMQ PEVAATATST AVSNMIIKAA ADFITTQEQE
QHHYHHHGRI HSHSPQAAVG VSGNPAETAS DPLVDLLLNH SNTPETAAAA AAAVAVEAAN
FQSMNHSHHS HHGHHGHSHG HGHSRVTGHV SGHVTSHHRG HHLPVVPPTP QESLIVALAS
ENALQKSVAT AAVTTNGAVM TQQASAPNTA GSILPAAVGA VAAAAAVAVQ PPIPQELTTM
SDQDLISYIN PSTFDQL
//
