ID A8KCI3_9BURK Unreviewed; 515 AA.
AC A8KCI3;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|HAMAP-Rule:MF_00229};
DE Short=Histidase {ECO:0000256|HAMAP-Rule:MF_00229};
DE EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|HAMAP-Rule:MF_00229};
GN Name=hutH {ECO:0000256|HAMAP-Rule:MF_00229,
GN ECO:0000313|EMBL:CAL80815.1};
GN ORFNames=AAW51_2395 {ECO:0000313|EMBL:AKJ29086.1};
OS Caldimonas brevitalea.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Caldimonas.
OX NCBI_TaxID=413882 {ECO:0000313|EMBL:CAL80815.1};
RN [1] {ECO:0000313|EMBL:CAL80815.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type strain: K481-B101 {ECO:0000313|EMBL:CAL80815.1};
RX PubMed=17564599; DOI=10.1111/j.1462-2920.2007.01278.x;
RA Schellenberg B., Bigler L., Dudler R.;
RT "Identification of genes involved in the biosynthesis of the cytotoxic
RT compound glidobactin from a soil bacterium.";
RL Environ. Microbiol. 9:1640-1650(2007).
RN [2] {ECO:0000313|EMBL:AKJ29086.1, ECO:0000313|Proteomes:UP000035352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7029 {ECO:0000313|EMBL:AKJ29086.1,
RC ECO:0000313|Proteomes:UP000035352};
RA Tang B., Yu Y.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00000171, ECO:0000256|HAMAP-
CC Rule:MF_00229, ECO:0000256|RuleBase:RU004479};
CC -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|HAMAP-Rule:MF_00229,
CC ECO:0000256|RuleBase:RU004479}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00229,
CC ECO:0000256|RuleBase:RU004480}.
CC -!- PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which
CC is formed autocatalytically by cyclization and dehydration of residues
CC Ala-Ser-Gly. {ECO:0000256|HAMAP-Rule:MF_00229}.
CC -!- SIMILARITY: Belongs to the PAL/histidase family. {ECO:0000256|HAMAP-
CC Rule:MF_00229, ECO:0000256|RuleBase:RU003954}.
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DR EMBL; CP011371; AKJ29086.1; -; Genomic_DNA.
DR EMBL; AM412319; CAL80815.1; -; Genomic_DNA.
DR RefSeq; WP_047194807.1; NZ_CP011371.1.
DR AlphaFoldDB; A8KCI3; -.
DR STRING; 413882.AAW51_2395; -.
DR KEGG; pbh:AAW51_2395; -.
DR PATRIC; fig|413882.6.peg.2507; -.
DR OrthoDB; 9806955at2; -.
DR UniPathway; UPA00379; UER00549.
DR Proteomes; UP000035352; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR CDD; cd00332; PAL-HAL; 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00229; His_ammonia_lyase; 1.
DR InterPro; IPR001106; Aromatic_Lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR005921; HutH.
DR InterPro; IPR008948; L-Aspartase-like.
DR InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR NCBIfam; TIGR01225; hutH; 1.
DR PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR Pfam; PF00221; Lyase_aromatic; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00488; PAL_HISTIDASE; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00229};
KW Histidine metabolism {ECO:0000256|ARBA:ARBA00022808, ECO:0000256|HAMAP-
KW Rule:MF_00229};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00229};
KW Reference proteome {ECO:0000313|Proteomes:UP000035352}.
FT MOD_RES 147
FT /note="2,3-didehydroalanine (Ser)"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00229"
FT CROSSLNK 146..148
FT /note="5-imidazolinone (Ala-Gly)"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00229"
SQ SEQUENCE 515 AA; 54132 MW; 3C2A370A73B28F45 CRC64;
MSPSERLTLH PGRLGLLDLR GIAAAFQPIE LDLECRAGIA ASAATVQRIS AGAEPAYGIN
TGFGKLAKVQ IPHDQLAQLQ ANLVRSHAVG VGPLLDDDTV RLVLALKIAS LARGYSGVRP
EVIDALVAMF NAQIWPCIPS QGSVGASGDL APLAHLTLPL MGEGEVRVDG RIVPAAQALQ
RAGLQPVRFA PKEGLALLNG TQVSTGIALM GLLRAEQVFA AAVVAGALSV DAAKGSDAPF
DDRIQQVRGH RGQIEVAALY RDLLAGSAIR ASHRTGDDRV QDPYSLRCQP QVMGACLELI
RNAAATLVIE ANAVSDNPLV FADSGEVLSG GNFHAEPVAF AADTLALAIA EVGALSERRI
ALLIDASLSG LPPFLVQEPG LNSGFMIAHV TAAALASENK TLAHPASVDS LPTSANQEDH
VSMATFAARK LADMALNVRH IIAIELLAAA QGIDFHRPLR SSQPLEEAHA AIRRRVPHYT
QDRYFAPDIA AVEQLIDAGS FTPYAGQVLP SWSRS
//
