ID A8L1T2_FRASN Unreviewed; 673 AA.
AC A8L1T2;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=DNA-directed DNA polymerase {ECO:0000313|EMBL:ABW13154.1};
GN ORFNames=Franean1_3759 {ECO:0000313|EMBL:ABW13154.1};
OS Frankia sp. (strain EAN1pec).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW13154.1};
RN [1] {ECO:0000313|EMBL:ABW13154.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW13154.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT "Complete sequence of Frankia sp. EAN1pec.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CP000820; ABW13154.1; -; Genomic_DNA.
DR AlphaFoldDB; A8L1T2; -.
DR STRING; 298653.Franean1_3759; -.
DR KEGG; fre:Franean1_3759; -.
DR eggNOG; COG0749; Bacteria.
DR HOGENOM; CLU_035229_0_0_11; -.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 2.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000313|EMBL:ABW13154.1};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABW13154.1};
KW Transferase {ECO:0000313|EMBL:ABW13154.1}.
FT DOMAIN 431..631
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 113..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 68515 MW; 32A315120D6F4E90 CRC64;
MVPTSRPVGT PAAAGAGSGA AAGSGAAAGA GAGAVAALRA AGVGRGGLVA VVPVSDVAVA
LACAGAVWAQ PADPAAVLAE VECALAPRWV WWSAHSTGAL LTRSGASTIA GPRTGSGAYA
GPGTHAGPGA GTGPGRSPIP AVCWDLAAAH RVLYGGHRDD PAAVWAGARG LPLPPPPPRP
RADGQLDLLA LVDHPGGPGD GEADDPIGPD GQLRPGWAEE TLRGAGPGGT GAQLARATRL
AQLALTVTAA QDEALRALPD PRARPAGLPL AVLTARAESG AELLARELRR DGLPVDRPTA
EATIAAAVGP RPDGDAAGAA ARQARDAPVL RHLGTSVDLR NPVAVRSALA AVGIDVPDTR
SGRLSALRGV HPVVEALLAW RKAERIATTY GYRWLDTHVG ADGRLRGEWR GSDGAAGRMT
AAAGLHNLPA DLRVVVIAEP GYRFVRADLG QIEPRVLAVV SGDPELTRAT RQDDLYAPVA
ASLGVDRPTA KVAVLAAMYG QTTGVAGQAL RQMRETYPVA LAYLDAADAT GRAAALGRPP
PNPPVTDPQA RLRTFGGRRV PLRFAAVDDG ADENRVGMTW GRFARNAVVQ GAAAELFKAW
AVTVRQAIAP LGGAIVLCLH DELLLHVPAP RAEAAAEATR RALDATVGYW AAGSGVRFVV
DIAVVRRWSD AKA
//
