ID A8L5B4_FRASN Unreviewed; 596 AA.
AC A8L5B4;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Hydrogen:quinone oxidoreductase {ECO:0000313|EMBL:ABW11924.1};
DE EC=1.12.5.1 {ECO:0000313|EMBL:ABW11924.1};
GN ORFNames=Franean1_2492 {ECO:0000313|EMBL:ABW11924.1};
OS Frankia sp. (strain EAN1pec).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW11924.1};
RN [1] {ECO:0000313|EMBL:ABW11924.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW11924.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT "Complete sequence of Frankia sp. EAN1pec.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
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DR EMBL; CP000820; ABW11924.1; -; Genomic_DNA.
DR AlphaFoldDB; A8L5B4; -.
DR STRING; 298653.Franean1_2492; -.
DR KEGG; fre:Franean1_2492; -.
DR eggNOG; COG0374; Bacteria.
DR HOGENOM; CLU_030087_0_0_11; -.
DR GO; GO:0047067; F:hydrogen:quinone oxidoreductase activity; IEA:UniProtKB-EC.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR InterPro; IPR001501; Ni-dep_hyd_lsu.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR42958:SF4; HYDROGENASE EXPRESSION_FORMATION PROTEIN HUPK; 1.
DR PANTHER; PTHR42958; HYDROGENASE-2 LARGE CHAIN; 1.
DR Pfam; PF00374; NiFeSe_Hases; 2.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|PIRSR:PIRSR601501-1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR601501-1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601501-1};
KW Nickel {ECO:0000256|PIRSR:PIRSR601501-1};
KW Oxidoreductase {ECO:0000313|EMBL:ABW11924.1}.
FT BINDING 78
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 81
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 81
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 568
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 571
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 574
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
SQ SEQUENCE 596 AA; 67341 MW; 59C30BD83521E2B9 CRC64;
MTTTSEHRGT DARGASLLEM SWDPITRIVG SLGVYTKIDW PARRVVECHS TSSIFRGYSI
FMKDKDPRDA HFITSRICGI CGDNHATCSV YAQNMAYGVK PPPLAEWIIN LGEAAEYMFD
HCIYQENLVG VDYCEKMVGE TNPEVLELAW ATESPHADEH GYRTIGDIMH ALNPIEGEFY
REALGMSRLT REMFCLMEGR HVHPSTLYPG GVGTVASVQL FTDYLTRLMR YIEFLKRVVP
MHDDLFDFFY KALPGYEEVG RRRILLGCWG AFNEPERCDF TYRNMADWGR SMFVTPGVVV
DGNLVTNNLV DINLGIRVLL GSSYYDDWDD QPLFVTHDPL GNPVDRRHPW NQTTIPHPSR
RDFDDKYSWV MSPRWFDGID HLPLDTGGGP IARLWSTALS GLVDIGHVRA TGHSVRITLP
RSATVGERTY EWTIPRWSNT LERNRARTYF QAYAAACALY FAEQALAEVR AGHSKTWESF
DVPDEAVSCG FTEAVRGVLS HHMIIRDGRI ANYHPYPPTP WNASVRDVFG TPGPYEDAVQ
NTPIFEQNPP ESFKGIDIMR TVRSFDPCLP CGVHMHTGAG RTLDVVHTPH AFTPAG
//
