ID A8LEM7_FRASN Unreviewed; 332 AA.
AC A8LEM7;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) {ECO:0000313|EMBL:ABW14089.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:ABW14089.1};
GN ORFNames=Franean1_4722 {ECO:0000313|EMBL:ABW14089.1};
OS Frankia sp. (strain EAN1pec).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=298653 {ECO:0000313|EMBL:ABW14089.1};
RN [1] {ECO:0000313|EMBL:ABW14089.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EAN1.pec {ECO:0000313|EMBL:ABW14089.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N.,
RA Israni S., Dalin E., Tice H., Pitluck S., Saunders E., Brettin T.,
RA Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Kim E., Rawnsley T., Niemann J., Benson D.R., Huang Y.,
RA Mastronunzio J., Bassi C.A., Tisa L.S., Richardson P.;
RT "Complete sequence of Frankia sp. EAN1pec.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP000820; ABW14089.1; -; Genomic_DNA.
DR AlphaFoldDB; A8LEM7; -.
DR STRING; 298653.Franean1_4722; -.
DR KEGG; fre:Franean1_4722; -.
DR eggNOG; COG1071; Bacteria.
DR HOGENOM; CLU_029393_5_0_11; -.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ABW14089.1}; Pyruvate {ECO:0000313|EMBL:ABW14089.1}.
FT DOMAIN 22..313
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 332 AA; 35287 MW; F320AE333CA14DB8 CRC64;
MTTDRTAGIS GQVWRRLYEL MTLMKAADDR LSRGIASGEL QCVYWPPRGQ EAIAAAMGVC
LRSDDQLVTT YRGLHDLIGK GVPLVEIYGE MLGRQVGSGR GKGGTMHIAR PDSGVMLSTG
IVGSGPPVAV GMAMAARRKG LDRVTAVSFG DGATNTGSFH EAANMAALWD LPLVLVCQNN
QYGEMTPTEH TMKIAQVADR AGGYGMPGVR VDGNDPLAVL AVLTQAVERA RSGGGPTLVE
CVTFRFRGHY FGDPMAYIPA ERMAAAVEAD PIPRFRSRLL ETGVCDEHEL DEIEAAAVAA
VEEALTAVLA APVAALDELD RDVYADPRNC PA
//
