ID A8MTE9_HUMAN Unreviewed; 669 AA.
AC A8MTE9;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Tetratricopeptide repeat domain 12 {ECO:0000313|Ensembl:ENSP00000376743.1};
GN Name=TTC12 {ECO:0000313|Ensembl:ENSP00000376743.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376743.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000376743.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000376743.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP000880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A8MTE9; -.
DR SMR; A8MTE9; -.
DR MassIVE; A8MTE9; -.
DR MaxQB; A8MTE9; -.
DR PeptideAtlas; A8MTE9; -.
DR ProteomicsDB; 2016; -.
DR Antibodypedia; 32178; 88 antibodies from 18 providers.
DR Ensembl; ENST00000393020.5; ENSP00000376743.1; ENSG00000149292.17.
DR UCSC; uc058hla.1; human.
DR HGNC; HGNC:23700; TTC12.
DR VEuPathDB; HostDB:ENSG00000149292; -.
DR GeneTree; ENSGT00940000161758; -.
DR ChiTaRS; TTC12; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000149292; Expressed in sperm and 137 other cell types or tissues.
DR ExpressionAtlas; A8MTE9; baseline and differential.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR043195; TTC12.
DR PANTHER; PTHR46540; TETRATRICOPEPTIDE REPEAT PROTEIN 12; 1.
DR PANTHER; PTHR46540:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 12; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A8MTE9,
KW ECO:0007829|MaxQB:A8MTE9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 174..207
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 669 AA; 75362 MW; 6D8856459F4C710B CRC64;
MDADKEKDLQ KFLKNVDEIS NLIQEMNSDD PVVQQKAVLE TEKRLLLMEE DQEEDECRTT
LNKTMISPPQ TAMKSAEEIN SEAFLASVEK DAKERAKRRR ENKVLADALK EKGNEAFAEG
NYETAILRYS EGLEKLKDMK VLYTNRAQAY MKLEDYEKAL VDCEWALKCD EKCTKAYFHM
GKANLALKNY SVSRECYKKI LEINPKLQTQ VKGYLNQVDL QEKADLQEKE AHELLDSGKN
TAVTTKNLLE TLSKPDQIPL FYAGGIEILT EMINECTEQT LFRMHNGFSI ISDNEVIRRC
FSTAGNDAVE EMVCVSVLKL WQAVCSRNEE NQRVLVIHHD RARLLAALLS SKVLAIRQQS
FALLLHLAQT ESGRSLIINH LDLTRLLEAL VSFLDFSDKE ANTAMGLFTD LALEERFQVW
FQANLPGVLP ALTGVLKTDP KVSSSSALCQ CIAIMGNLSA EPTTRRHMAA CEEFGDGCLS
LLARCEEDVD LFREVIYTLL GLMMNLCLQA PFVSEVWAVE VSRRCLSLLN SQDGGILTRA
AGVLSRTLSS SLKIVEEALR AGVVKKMMKF LKTGGETASR YAIKILAICT NSYHEAREEV
IRLDKRAPTP PLETRLVPGN QSLLVQQAEE LGFSILKRMW PGWNSITILK PQQRWQNSLG
PHPSGCVYQ
//
