GenomeNet

Database: UniProt
Entry: A8MTZ5_HUMAN
LinkDB: A8MTZ5_HUMAN
Original site: A8MTZ5_HUMAN 
ID   A8MTZ5_HUMAN            Unreviewed;        61 AA.
AC   A8MTZ5;
DT   04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT   04-DEC-2007, sequence version 1.
DT   11-DEC-2019, entry version 82.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 15 {ECO:0000313|Ensembl:ENSP00000381899};
DE   Flags: Fragment;
GN   Name=KCNJ15 {ECO:0000313|Ensembl:ENSP00000381899};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000381899, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000381899, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10830953; DOI=10.1038/35012518;
RG   Chromosome 21 mapping and sequencing consortium;
RA   Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA   Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA   Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA   Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA   Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA   Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA   Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA   Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA   Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA   Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA   Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT   "The DNA sequence of human chromosome 21.";
RL   Nature 405:311-319(2000).
RN   [2] {ECO:0000313|Ensembl:ENSP00000381899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP001417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP001434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457277; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF457286; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF495693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; A8MTZ5; -.
DR   PRIDE; A8MTZ5; -.
DR   ProteomicsDB; 2065; -.
DR   Ensembl; ENST00000398925; ENSP00000381899; ENSG00000157551.
DR   UCSC; uc062abs.1; human.
DR   EuPathDB; HostDB:ENSG00000157551.17; -.
DR   HGNC; HGNC:6261; KCNJ15.
DR   OpenTargets; ENSG00000157551; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00980000198471; -.
DR   HOGENOM; HOG000200050; -.
DR   ChiTaRS; KCNJ15; human.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000157551; Expressed in 169 organ(s), highest expression level in nephron tubule.
DR   ExpressionAtlas; A8MTZ5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003270; K_chnl_inward-rec_Kir1.3.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF20; PTHR11767:SF20; 1.
DR   Pfam; PF01007; IRK; 1.
DR   PRINTS; PR01323; KIR13CHANNEL.
PE   1: Evidence at protein level;
KW   Ion channel {ECO:0000256|RuleBase:RU003822};
KW   Ion transport {ECO:0000256|RuleBase:RU003822};
KW   Membrane {ECO:0000256|RuleBase:RU003822};
KW   Potassium {ECO:0000256|RuleBase:RU003822};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A8MTZ5,
KW   ECO:0000213|ProteomicsDB:A8MTZ5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822};
KW   Transport {ECO:0000256|RuleBase:RU003822};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822}.
FT   DOMAIN          30..61
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   NON_TER         61
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000381899"
SQ   SEQUENCE   61 AA;  6724 MW;  6D9803F9E4886A9E CRC64;
     MDAIHIGMSS TPLVKHTAGA GLKANRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID
     M
//
DBGET integrated database retrieval system