ID A8MU27_HUMAN Unreviewed; 147 AA.
AC A8MU27;
DT 04-DEC-2007, integrated into UniProtKB/TrEMBL.
DT 04-DEC-2007, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=Small ubiquitin like modifier 3 {ECO:0000313|Ensembl:ENSP00000380990.3};
GN Name=SUMO3 {ECO:0000313|Ensembl:ENSP00000380990.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000380990.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000380990.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RG Chromosome 21 mapping and sequencing consortium;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:25218447}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
RN [4] {ECO:0007829|PubMed:25114211}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25114211;
RA Impens F., Radoshevich L., Cossart P., Ribet D.;
RT "Mapping of SUMO sites and analysis of SUMOylation changes induced by
RT external stimuli.";
RL Proc. Natl. Acad. Sci. U.S.A. 111:12432-12437(2014).
RN [5] {ECO:0007829|PubMed:25772364}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25772364; DOI=10.1016/j.celrep.2015.02.033;
RA Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V.,
RA Vertegaal A.C.;
RT "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.";
RL Cell Rep. 10:1778-1791(2015).
RN [6] {ECO:0007829|PubMed:25755297}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25755297; DOI=10.1074/mcp.O114.044792;
RA Xiao Z., Chang J.G., Hendriks I.A., Sigurethsson J.O., Olsen J.V.,
RA Vertegaal A.C.;
RT "System-wide analysis of SUMOylation dynamics in response to replication
RT stress reveals novel small ubiquitin-like modified target proteins and
RT acceptor lysines relevant for genome stability.";
RL Mol. Cell. Proteomics 14:1419-1434(2015).
RN [7] {ECO:0007829|PubMed:28112733}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
RN [8] {ECO:0000313|Ensembl:ENSP00000380990.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin family. SUMO subfamily.
CC {ECO:0000256|ARBA:ARBA00009185}.
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DR EMBL; AL773603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A8MU27; -.
DR SMR; A8MU27; -.
DR EPD; A8MU27; -.
DR MassIVE; A8MU27; -.
DR MaxQB; A8MU27; -.
DR ProteomicsDB; 2075; -.
DR Antibodypedia; 24332; 560 antibodies from 40 providers.
DR Ensembl; ENST00000397893.3; ENSP00000380990.3; ENSG00000184900.16.
DR UCSC; uc062ato.1; human.
DR HGNC; HGNC:11124; SUMO3.
DR VEuPathDB; HostDB:ENSG00000184900; -.
DR GeneTree; ENSGT00950000182895; -.
DR HOGENOM; CLU_1781595_0_0_1; -.
DR PhylomeDB; A8MU27; -.
DR ChiTaRS; SUMO3; human.
DR Proteomes; UP000005640; Chromosome 21.
DR Bgee; ENSG00000184900; Expressed in endothelial cell and 215 other cell types or tissues.
DR ExpressionAtlas; A8MU27; baseline and differential.
DR GO; GO:0016925; P:protein sumoylation; IEA:UniProt.
DR CDD; cd16115; Ubl_SUMO2_3_4; 1.
DR InterPro; IPR022617; Rad60/SUMO-like_dom.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10562; SMALL UBIQUITIN-RELATED MODIFIER; 1.
DR PANTHER; PTHR10562:SF135; SMALL UBIQUITIN-RELATED MODIFIER 3; 1.
DR Pfam; PF11976; Rad60-SLD; 1.
DR PRINTS; PR02045; F138DOMAIN.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A8MU27,
KW ECO:0007829|MaxQB:A8MU27};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 17..88
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|SMART:SM00213"
SQ SEQUENCE 147 AA; 16957 MW; 2F9BC6BFAAB8658D CRC64;
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ GLSMRQIRFR
FDGQPINETD TPAQGIILSW KELWTWKQTF FFETESRFVA QARMQWRSLS SLCKLCLLSS
RHSPASASQV AGTIGAHHHS RLIFLYF
//
