ID A8N4N8_COPC7 Unreviewed; 358 AA.
AC A8N4N8;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Tyrosinase central domain-containing protein {ECO:0000313|EMBL:EAU92029.1};
GN ORFNames=CC1G_06016 {ECO:0000313|EMBL:EAU92029.1};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU92029.1, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU92029.1, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU92029.1}.
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DR EMBL; AACS02000003; EAU92029.1; -; Genomic_DNA.
DR RefSeq; XP_001829807.1; XM_001829755.1.
DR AlphaFoldDB; A8N4N8; -.
DR STRING; 240176.A8N4N8; -.
DR GeneID; 6006244; -.
DR KEGG; cci:CC1G_06016; -.
DR VEuPathDB; FungiDB:CC1G_06016; -.
DR eggNOG; ENOG502RM4B; Eukaryota.
DR InParanoid; A8N4N8; -.
DR OMA; DGCITDG; -.
DR OrthoDB; 4070889at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..358
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002726201"
FT DOMAIN 281..292
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 358 AA; 39555 MW; C4A897729696055F CRC64;
MVLFTQLLPF LAIFCANFAG IVSTPIPGGS QAKQECDSIE IRREWRDLTV EQRLDYLRAV
KCLQETPANI ETSRKEIKTR YDQFQAAHFD LAFQVHGVGQ FLAWHRHFVT LYHKALRDDC
GYEGPATYWD WTRDADGPGL FKDSPVFDDV TGFGGNGVPG TSEPLPPIPA PGLPPLPGFP
EGPRAPAGCV QTGPFKDHLV NFGPGQSIGA PSCIIRAIYE DVRDNVNSTS VAAQMAQTNF
EDFRNFLELQ GPPLAVGAGL HWAGHAIVGG MMMDGWSAPG DPLFYLHHGN LDRIWYKWQM
DDPENRLYAI SGPSSVRPPS NDNVTRDFMM PYATVSEPVA VGDVMDTEAY PGCFKYVD
//
