ID A8N501_COPC7 Unreviewed; 740 AA.
AC A8N501;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CC1G_04579 {ECO:0000313|EMBL:EAU91812.2};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU91812.2, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU91812.2, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU91812.2}.
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DR EMBL; AACS02000003; EAU91812.2; -; Genomic_DNA.
DR RefSeq; XP_001829890.2; XM_001829838.2.
DR AlphaFoldDB; A8N501; -.
DR STRING; 240176.A8N501; -.
DR GeneID; 6006327; -.
DR KEGG; cci:CC1G_04579; -.
DR VEuPathDB; FungiDB:CC1G_04579; -.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_375056_0_0_1; -.
DR InParanoid; A8N501; -.
DR OMA; RRTINIE; -.
DR OrthoDB; 1654409at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF05970; PIF1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT REGION 20..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 82323 MW; DF9B2CB555BD0FFD CRC64;
MEQVQATLSP QDKQRLENMS LLAEGRESRA SFPRQTKTDD LRDWDGLPEG VDDTESTPVS
RNVFDCVVND ASEFDNQYNE PLEPLLNVDV INAFARCYYS DSQGMKLTKS DSVVPKTELL
LANARTAYVK LTAPHTDHYQ ESVDTDFNGD LIAITQATQQ ELPSVSTERL ANGITNFTVD
DSVSETTIAN GRRSIPHHVI EEMNMGNNRE QRRAFSIIAD HILDGGPQLL MYVGGMGGTG
KSHVIRAVVM LLERLGRRHE LLIGAPTGIA ATLIGGTTLH SLILANPGRK GEGTANERLT
RIWANIRYLI VDEVSMVGAQ FLAEMSSKIR IAKGNDPQAR TRPFGGVSVI FTGDFCQLTP
PRQTSLFSHS LVRDPSFLQS RDNDGIDSLA GAYLWRLVGT VVILTSNQRQ KTDPTFARAL
ELIRMRRCYD SLGHSEIINE TPIYEYLRNR ELVRVARENP ESLRAFLDAP VIVGSKLLQD
ALNAKLVKFN ADRQKEEVCL YHSLDSSHRQ PIAHEPLRTQ LWNLSSRKNS ESLGKLPLFV
GMKVMITENV SITHKAVNGA EGTVVQIVYS ENKEGLRFAE VVYVQIPGSG IQLHTLPPET
LPLFPTSTTI KHHIKSATLA ARSFTRKQVP LVPAYSYTDY KSQGRSLSRA IVDISTARGQ
GVYVMLSRVK WLEGLLILRS FPASKIFESM SGELRSELNR LTILDVATEA AYQSRQNPGN
CYEVLSHSPD DLIMLPDHSK
//
