ID A8NFB1_COPC7 Unreviewed; 347 AA.
AC A8NFB1;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Dihydrodipicolinate synthetase {ECO:0000313|EMBL:EAU88513.1};
GN ORFNames=CC1G_04219 {ECO:0000313|EMBL:EAU88513.1};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU88513.1, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU88513.1, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- SIMILARITY: Belongs to the DapA family.
CC {ECO:0000256|PIRNR:PIRNR001365}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU88513.1}.
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DR EMBL; AACS02000002; EAU88513.1; -; Genomic_DNA.
DR RefSeq; XP_001833240.1; XM_001833188.2.
DR AlphaFoldDB; A8NFB1; -.
DR STRING; 240176.A8NFB1; -.
DR GeneID; 6009735; -.
DR KEGG; cci:CC1G_04219; -.
DR VEuPathDB; FungiDB:CC1G_04219; -.
DR eggNOG; ENOG502QWNS; Eukaryota.
DR InParanoid; A8NFB1; -.
DR OMA; ADYSIVI; -.
DR OrthoDB; 1780992at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR CDD; cd00408; DHDPS-like; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR002220; DapA-like.
DR PANTHER; PTHR12128:SF72; 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12128; DIHYDRODIPICOLINATE SYNTHASE; 1.
DR Pfam; PF00701; DHDPS; 1.
DR PIRSF; PIRSF001365; DHDPS; 1.
DR PRINTS; PR00146; DHPICSNTHASE.
DR SMART; SM01130; DHDPS; 1.
DR SUPFAM; SSF51569; Aldolase; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|PIRNR:PIRNR001365};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT ACT_SITE 157
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT ACT_SITE 187
FT /note="Schiff-base intermediate with substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-1"
FT BINDING 243
FT /ligand="pyruvate"
FT /ligand_id="ChEBI:CHEBI:15361"
FT /evidence="ECO:0000256|PIRSR:PIRSR001365-2"
SQ SEQUENCE 347 AA; 37029 MW; 33AD61D7B069B1D5 CRC64;
MNSNGILNGH SPIVRPLKPG IYAPIPTFFL PESEDLDLPT FERHLAKVAA AGVGPLIAGS
MGEAIHLSPD ERITLIRTAR KVLDEAGFVD VPIIAGTGAA STRETVQLTR QAAEAGADYA
IVIASGYFAG ALATNRQALK DYWTEVSEKS PIPVMIYNYP GASSGIDLDS DFIVDLAMTC
PNICGVKLTC GNVGKLTRIA EAIAEPSFTT KYPRKNSAAP FLVLGGFADF LLPSAFVEGH
GAIIGLANLA PYSTVKLFQL SEESKKDPSL LPEAQRIQGI VARGDFTIAK ASISGTKYLL
EKVYGYGGLT RRPLPPITPE AASAIWEHPH TQALVQLERE LSGKLRT
//
