ID A8NGA4_COPC7 Unreviewed; 1167 AA.
AC A8NGA4;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 10-AUG-2010, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Vacuolar import and degradation protein 21 {ECO:0000256|ARBA:ARBA00029670};
GN ORFNames=CC1G_05088 {ECO:0000313|EMBL:EAU88322.2};
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176 {ECO:0000313|EMBL:EAU88322.2, ECO:0000313|Proteomes:UP000001861};
RN [1] {ECO:0000313|EMBL:EAU88322.2, ECO:0000313|Proteomes:UP000001861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003
RC {ECO:0000313|Proteomes:UP000001861};
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canback B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kues U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- FUNCTION: Component of the NuA4 histone acetyltransferase complex which
CC is involved in transcriptional activation of selected genes principally
CC by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is
CC also involved in DNA repair. {ECO:0000256|ARBA:ARBA00025178}.
CC -!- SIMILARITY: Belongs to the EAF1 family.
CC {ECO:0000256|ARBA:ARBA00008913}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU88322.2}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACS02000002; EAU88322.2; -; Genomic_DNA.
DR RefSeq; XP_001833388.2; XM_001833336.2.
DR AlphaFoldDB; A8NGA4; -.
DR STRING; 240176.A8NGA4; -.
DR GeneID; 6009884; -.
DR KEGG; cci:CC1G_05088; -.
DR VEuPathDB; FungiDB:CC1G_05088; -.
DR eggNOG; ENOG502RGMX; Eukaryota.
DR HOGENOM; CLU_006074_0_0_1; -.
DR InParanoid; A8NGA4; -.
DR OMA; HDWMLAR; -.
DR OrthoDB; 1334563at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:UniProt.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR014012; HSA_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR46459:SF1; E1A-BINDING PROTEIN P400; 1.
DR PANTHER; PTHR46459; E1A-BINDING PROTEIN P400-RELATED; 1.
DR Pfam; PF07529; HSA; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR SMART; SM00573; HSA; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51204; HSA; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Reference proteome {ECO:0000313|Proteomes:UP000001861}.
FT DOMAIN 318..399
FT /note="HSA"
FT /evidence="ECO:0000259|PROSITE:PS51204"
FT DOMAIN 713..761
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1043..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 815..832
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..863
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..944
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1167 AA; 127219 MW; 04934AD226A9D4FD CRC64;
MTAPPKANPI QTTQQSTSAS VPGEATGTTT GQEGPSDAGN DLPVTGTRVS QGLTKEEIDD
DRDELDLIGS TDKDGTGSSS PSKAHPEPSD QQRDSSQSAA PPPSSSPSLQ SLPASSSQVQ
SLGQADQEPT KGMSSDVSMV DVSEESVKGN ATTVNPLAVY KPSVSSSIFV QPTPNPVIIP
EPLAPSVSKD QYDIQQPPPP EPKVEPSSPV LRYGIKTEYT LPSLQILPPE FTRKKSSKRR
KDRERPEKSQ KDDGVPMGIN RWAAMLNANP LYKRVARSTK CLSTKEWSVA IAELRLIRTA
ERIEVLKSQA RWGLRQIKKQ RGVGGLLKTH WDYLLDEMKW MRTDFREERK WKLAVAYQLS
TSVLEWHSLK NFEERVQHGV CVKWRPHEPV TLDDNQVDSQ SMDIDMESSG NDPEANPVPS
NSILGLDYAS DNEDMDGDSE KQLEVMDPLE TGNAIKDALD GADEARMKEA EPTPMEEVKL
KTEEIDDTVA LQGPMVVDTA QAEALEKSAL KSTSNDPLLG SKSSSHSLNG DGDEKPPSTK
TKIAAYAPIR EKLVYESEGK LFIEPEDLHI PDQEDTDSLR QLDISSIFPD LQPFAMFDVA
PATEPKKKNR IERDDPNKRL EETNYTKVFP SGQFMFVKPT LLGPLQPAKR WKDGSWLPME
ENPIPSEPES GSTSVKNLEE SVSELFDFKI KTSGPALPPQ ARDARRAKVD QYWSTNDDLL
LKSLVDKYPG NWNLIAECFN GCRKTTPSDR RTPTDCMDRW KVKWGMDLLT KDNPQGNSED
QSPPTGVQAS SSNDISMSNS TPSVAAGPSV TTRGVRRLAS ASVSSQVAPS VSAGNEPKKR
RRHLLLQETI RKTNRKKADQ QAKQLANQRK TPGMHETHIQ YTKLPRLSPM ELSRLKAERD
AAQLAEIQKA RARQEELKKQ LSGIPIPPQA GQPQPGPQTP VPHAQGGQPQ PLTQQQQLQL
QAQLQANQAR AGSVGAPGTR PGSVNIARMS TPTGVAVAGP PRLTSQQVLQ LQQRLAAGTG
QTALNAATVN LANGLVNSQF GNRDATASPA THGVNSPHLA PSSGNAAVNP PRSPHDPAAV
NAAVGQAMNA VGAANGAQRA AFNLQFQNGQ TQNLHPDQIN ALRIHMLVGC GFISMDENIR
THTGPLNRNL NHNLSLNLLH KVEAILP
//
