ID A8PK49_9COXI Unreviewed; 169 AA.
AC A8PK49;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=tRNA(adenine(34)) deaminase {ECO:0000256|ARBA:ARBA00012740};
DE EC=3.5.4.33 {ECO:0000256|ARBA:ARBA00012740};
GN ORFNames=RICGR_0300 {ECO:0000313|EMBL:EDP46493.1};
OS Rickettsiella grylli.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales; Coxiellaceae;
OC Rickettsiella.
OX NCBI_TaxID=59196 {ECO:0000313|EMBL:EDP46493.1, ECO:0000313|Proteomes:UP000054075};
RN [1] {ECO:0000313|EMBL:EDP46493.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Seshadri R., Federici B.A.;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDP46493.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Myers G.S.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
CC Evidence={ECO:0000256|ARBA:ARBA00001103};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP46493.1}.
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DR EMBL; AAQJ02000001; EDP46493.1; -; Genomic_DNA.
DR RefSeq; WP_006035469.1; NZ_AAQJ02000001.1.
DR AlphaFoldDB; A8PK49; -.
DR STRING; 59196.RICGR_0300; -.
DR eggNOG; COG0590; Bacteria.
DR OrthoDB; 9802676at2; -.
DR Proteomes; UP000054075; Unassembled WGS sequence.
DR GO; GO:0102480; F:5-fluorocytosine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0004131; F:cytosine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0052717; F:tRNA-specific adenosine-34 deaminase activity; IEA:RHEA.
DR GO; GO:0002100; P:tRNA wobble adenosine to inosine editing; IEA:InterPro.
DR CDD; cd01285; nucleoside_deaminase; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR InterPro; IPR002125; CMP_dCMP_dom.
DR InterPro; IPR016193; Cytidine_deaminase-like.
DR InterPro; IPR028883; tRNA_aden_deaminase.
DR PANTHER; PTHR11079:SF179; CYTOSINE DEAMINASE; 1.
DR PANTHER; PTHR11079; CYTOSINE DEAMINASE FAMILY MEMBER; 1.
DR Pfam; PF14437; MafB19-deam; 1.
DR SUPFAM; SSF53927; Cytidine deaminase-like; 1.
DR PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:EDP46493.1};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 6..117
FT /note="CMP/dCMP-type deaminase"
FT /evidence="ECO:0000259|PROSITE:PS51747"
SQ SEQUENCE 169 AA; 19482 MW; 264D97A8289D1DE8 CRC64;
MAQLNKKERE FLDLAYQEAL LGLKEGGIPI GSILVVENKV RAKGRNKRIQ EHSMIKHGET
DCLENTRRKV LPEDLQRATL YTTLSPCSMC AGAILLHKIP RVIVGENKTF EQSELWLKQN
QTEVIVVNQE KCIAMMLSFI RKNLKLWGED IGLTEQQTLN KYKDLFQWI
//
