ID A8PVW2_MALGO Unreviewed; 641 AA.
AC A8PVW2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Tr-type G domain-containing protein {ECO:0000259|PROSITE:PS51722};
GN ORFNames=MGL_0969 {ECO:0000313|EMBL:EDP44487.1};
OS Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=425265 {ECO:0000313|EMBL:EDP44487.1, ECO:0000313|Proteomes:UP000008837};
RN [1] {ECO:0000313|EMBL:EDP44487.1, ECO:0000313|Proteomes:UP000008837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4612 / CBS 7966 {ECO:0000313|Proteomes:UP000008837};
RX PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA Kronstad J.W., Deangelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA Chu L., Sears R., Yuan B., Dawson T.L.Jr.;
RT "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT virulence traits shared with plant and human fungal pathogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP44487.1}.
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DR EMBL; AAYY01000003; EDP44487.1; -; Genomic_DNA.
DR RefSeq; XP_001731701.1; XM_001731649.1.
DR AlphaFoldDB; A8PVW2; -.
DR STRING; 425265.A8PVW2; -.
DR GeneID; 5856006; -.
DR KEGG; mgl:MGL_0969; -.
DR VEuPathDB; FungiDB:MGL_0969; -.
DR InParanoid; A8PVW2; -.
DR OMA; RYYNVIY; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000008837; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR CDD; cd03702; IF2_mtIF2_II; 1.
DR CDD; cd03692; mtIF2_IVc; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR044145; IF2_II.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF20; TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000008837}.
FT DOMAIN 64..240
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 641 AA; 69455 MW; 948041C79495AC0E CRC64;
MRKLQFRMEQ IGFDDTRPDR LLKLEDAELV AAEYNCVVSA SEEAAFDIYP RPEPSAEERA
KLPLRPPVVT IMGHVDHGKT TLLDTLRSTS VAQGEAGGIT QHIGAFSVPV NRPEGAISSV
TFLDTPGHAA FSTMRSRGTS VTDIVVLVVA ADDSVMPQTR EVISLVRDGE RKVPLVVAIT
KIDAPKADPH KVRYDLFAEG VEVEELGGDV PCVEVSAKQK QGLDTLDETL AVLAEMGELR
AETSGPAEGR ILESRVEKGR GNVATVLVQR GVLQSGDIIA CGTTWAKVRQ LLQPDGRSAK
QVLPGYAAQV AGWRELPKAG DEFLGALDEA KCKRAIEHRK RVLEEQALLY DAEQIDQERR
RKAEADALRE RTEQMTRKEL SRIQRAQEDG SLDADAVAKA VREQRLAAEL AAKGDAGASA
GAGGKAERAE LNLILKGDVS GTVEALAGAV SHIGNAAAGV RIVSQSVGDP TESDVNTAHA
IGAHIIGFHV KAPKSIQTSA SRCQPPVPLH CDDVIYRLMD HVTDKVAALL PPIDEMRVLG
EANVAQLFHI KQGQRRAPKC IAGCRVTNGT VSRANEIRIL RGDERKEVFR GRLDTLRQVK
KDVSEMRKGT ECGMSFDGFD DVQIDDKIQC FTMVQVPATL K
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