ID A8Q2Y7_MALGO Unreviewed; 700 AA.
AC A8Q2Y7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 03-MAY-2023, entry version 75.
DE RecName: Full=serine--tRNA ligase {ECO:0000256|ARBA:ARBA00012840};
DE EC=6.1.1.11 {ECO:0000256|ARBA:ARBA00012840};
DE AltName: Full=Seryl-tRNA synthetase {ECO:0000256|ARBA:ARBA00031113};
DE AltName: Full=Seryl-tRNA(Ser) synthetase {ECO:0000256|ARBA:ARBA00034892};
GN ORFNames=MGL_2271 {ECO:0000313|EMBL:EDP43261.1};
OS Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX NCBI_TaxID=425265 {ECO:0000313|EMBL:EDP43261.1, ECO:0000313|Proteomes:UP000008837};
RN [1] {ECO:0000313|EMBL:EDP43261.1, ECO:0000313|Proteomes:UP000008837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4612 / CBS 7966 {ECO:0000313|Proteomes:UP000008837};
RX PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA Kronstad J.W., Deangelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA Chu L., Sears R., Yuan B., Dawson T.L.Jr.;
RT "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT virulence traits shared with plant and human fungal pathogens.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP43261.1}.
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DR EMBL; AAYY01000008; EDP43261.1; -; Genomic_DNA.
DR RefSeq; XP_001730475.1; XM_001730423.1.
DR AlphaFoldDB; A8Q2Y7; -.
DR STRING; 425265.A8Q2Y7; -.
DR GeneID; 5854782; -.
DR KEGG; mgl:MGL_2271; -.
DR VEuPathDB; FungiDB:MGL_2271; -.
DR InParanoid; A8Q2Y7; -.
DR OMA; IEMFVAT; -.
DR OrthoDB; 239638at2759; -.
DR Proteomes; UP000008837; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004828; F:serine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro.
DR InterPro; IPR002314; aa-tRNA-synt_IIb.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR018811; Mrx11.
DR InterPro; IPR002317; Ser-tRNA-ligase_type_1.
DR InterPro; IPR010978; tRNA-bd_arm.
DR PANTHER; PTHR11778:SF7; SERINE--TRNA LIGASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR11778; SERYL-TRNA SYNTHETASE; 1.
DR Pfam; PF10306; FLILHELTA; 1.
DR Pfam; PF00587; tRNA-synt_2b; 1.
DR PRINTS; PR00981; TRNASYNTHSER.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR SUPFAM; SSF46589; tRNA-binding arm; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 4: Predicted;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008837};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 571..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..488
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT REGION 517..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..118
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 521..538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 700 AA; 77224 MW; F792E08F2844CA51 CRC64;
MYASKSAPPT GFRPLPEPSV SWRAEDVEEA RRVTLLRDMS FREDEAAALP SLQASLKQMR
YDRIKIEEEQ RHVGAMIPSL AKKVNTNAER VSQLRERARE LRTALRYLEK QMDEAHARSL
QIRSAWPNRM HPDVPIGPES ESRVVAVCDA RSPACRSTSL PTTLLPCTTH AFDASFTSKL
QVDPRRDHLG LAQSMSHGGV DMAAGITTTG PSWPYLLGTI SMLEHALCQY ALHVATRHGF
IPVSVPDVIK TDVAERCGFR PRDEVAAQTY FVDTKRSITT HDTSACDDAM ATLCLAGTAE
IPLAALVAKQ TFSHRHTQPN LGGDVASMHL PIRLTALGHA FRAEAGARGA DTRGLYRIHQ
FSKVEMFVVS DAEQSDAMLE SLRHVQEDIV NGLGLLYRVV DMSSEELGAS AYRKYDIEAW
MPGRGAWGEI CSASNCTEYQ ARRLAIKYRD AETGRNTYAH TLNATAAAIP RLLVALIETY
SSSNLVLPVA LRPFWIGGPS DTRVEWIEPA SVAASAPASS GERASPLQQC GTSHPRASFH
TSARRNVSAF TRAKEQLHSL AVRTGADPAP LLISFVILHE ITAIVPIFVL AALLAVLGAG
DAMLEWVNTL LNAMMPSENA RLYEWIARGR RMATRVCRRF DTLLRGKEGT PMAAAWFTSL
TASYVLVKLL LPVRIALSLA LSPVTARTLI MPWWRRFRRT
//
