ID   A8QCC4_MALGO            Unreviewed;      1178 AA.
AC   A8QCC4;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   22-FEB-2023, entry version 74.
DE   RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN   ORFNames=MGL_3993 {ECO:0000313|EMBL:EDP41612.1};
OS   Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=425265 {ECO:0000313|EMBL:EDP41612.1, ECO:0000313|Proteomes:UP000008837};
RN   [1] {ECO:0000313|EMBL:EDP41612.1, ECO:0000313|Proteomes:UP000008837}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4612 / CBS 7966 {ECO:0000313|Proteomes:UP000008837};
RX   PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA   Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA   Kronstad J.W., Deangelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA   Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA   Chu L., Sears R., Yuan B., Dawson T.L.Jr.;
RT   "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT   virulence traits shared with plant and human fungal pathogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDP41612.1}.
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DR   EMBL; AAYY01000018; EDP41612.1; -; Genomic_DNA.
DR   RefSeq; XP_001728826.1; XM_001728774.1.
DR   AlphaFoldDB; A8QCC4; -.
DR   STRING; 425265.A8QCC4; -.
DR   GeneID; 5853132; -.
DR   KEGG; mgl:MGL_3993; -.
DR   VEuPathDB; FungiDB:MGL_3993; -.
DR   InParanoid; A8QCC4; -.
DR   OrthoDB; 276824at2759; -.
DR   Proteomes; UP000008837; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR039762; Nmd2/UPF2.
DR   InterPro; IPR007193; Upf2/Nmd2_C.
DR   PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR   PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR   Pfam; PF02854; MIF4G; 2.
DR   Pfam; PF04050; Upf2; 1.
DR   SMART; SM00543; MIF4G; 2.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008837}.
FT   DOMAIN          450..637
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   DOMAIN          651..850
FT                   /note="MIF4G"
FT                   /evidence="ECO:0000259|SMART:SM00543"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          953..1060
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1086..1123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          286..313
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        957..1001
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1002..1056
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1178 AA;  135546 MW;  7604AEFEB6966A1B CRC64;
     MNDDPQKSDS QAENEVAHVP AREVSETAKI AEREQWRAAL RDANCKVWVE GPSSSDANLD
     TSLKRNSAFI KRLKQPNLGD AKDALLREVY TLSLAKYLDE LVPSVPEVLW KNSQPKDRYA
     VVEILSALHA RFGGAEFSCA MLKAISQELV PLPPRNNAEP PNEQAQKEEA LKVTRQRNLL
     RGATELVLVG LGGPVTGNGC VCAAGWDWLY EQLRTLLGQD RDLAYLPLVQ GMMRTFGSLL
     LIPMEEHEAG QSEAHLGGTA AAVSFDPVVP ETQSQKFRKL FEMYYIALVK RVKREYERLN
     EQERRNNDAY IRSGMIFEDR QAAFERRSKE LQTMIDAMQV MASSLNVFVP DLPASDKGTV
     SQRLGINLEA TSALAEMTAK IEQEYASGKS PWEDEETRKF YKDIFDLRER IPTALLDQAP
     QADEKEKEKE ALNEEAEMQT TMDNRSQSLQ NILERLPTLA NRTMVDDMAV ELGFHLKSVT
     NKRLVSHFMS APKHRWDLLP YYARMIAILH PYRAGLADMV VEQVNQKFRQ QYSYRKPDRQ
     MQSNVVICMG ELTKFGLVPD HIVFHTMKVL LDDFSPVAIE MLALLIETCG RYLYRMPLTM
     TRMQSMLDLM RRKRMAHNLS EQHSLLLDNA YYKCVPPERP VIVHREPTVM EQFITYLFTN
     LPSPNKTPHI RDLLLKLDWH DESIRAHLFM HFTSPWLVQH NNVRNLAELL NALRPMRYAF
     TTQVLDSLSE GIEADLLHLH FTWHQRRISR VRYLGELHRV GIVSVNELLN QVWRFCSRRY
     RRRDPRDDFT RVRLVCTLLP YCHSLIFDRP YDKRLRLITA IFQYYVQTKV EPPVEVAYLL
     QDTVQRCGLF KYMYTHREHL QKVVEDAVGY FSQQDLSSYV MWKKRKAYMQ AQRSQMHVNI
     KASVIDNVLE GAETKTKVET ERDAMTQAIP ETGDSAKNQP RGSARVNSIM DVEPDLYDNQ
     TRLDDEMVLS RQRRGTDAKD ELATENAFES EIDVKLEDEK DMDAEVSDEQ VDFDVKEGED
     EDEDEGEDRE CESEKDDEMS VDLDDDHEED ELLDDEEVKE QLRQEALDEK ADAELEQELA
     MLMADSGGNV SGAPSGAALE QTRLKLSDTQ VPRRRAAEPA SDQHMVFSLL SRKHTQDIQV
     PSEASISVHA RQQQAQAEAE RKQLKAYVLA YREREEQA
//