ID A8RDR2_9FIRM Unreviewed; 700 AA.
AC A8RDR2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=MMPL family protein {ECO:0000313|EMBL:EDP10765.1};
GN ORFNames=EUBDOL_02028 {ECO:0000313|EMBL:EDP10765.1};
OS Amedibacillus dolichus DSM 3991.
OC Bacteria; Bacillota; Erysipelotrichia; Erysipelotrichales;
OC Erysipelotrichaceae; Amedibacillus.
OX NCBI_TaxID=428127 {ECO:0000313|EMBL:EDP10765.1, ECO:0000313|Proteomes:UP000004090};
RN [1] {ECO:0000313|EMBL:EDP10765.1, ECO:0000313|Proteomes:UP000004090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3991 {ECO:0000313|EMBL:EDP10765.1,
RC ECO:0000313|Proteomes:UP000004090};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Eubacterium dolichum (DSM 3991).";
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EDP10765.1, ECO:0000313|Proteomes:UP000004090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 3991 {ECO:0000313|EMBL:EDP10765.1,
RC ECO:0000313|Proteomes:UP000004090};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Thiruvilangam P., Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP10765.1}.
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DR EMBL; ABAW02000024; EDP10765.1; -; Genomic_DNA.
DR AlphaFoldDB; A8RDR2; -.
DR STRING; 428127.EUBDOL_02028; -.
DR eggNOG; COG1033; Bacteria.
DR HOGENOM; CLU_007352_0_0_9; -.
DR Proteomes; UP000004090; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 184..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 555..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 551..682
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 700 AA; 76660 MW; AD6B3C80E4E3DEF5 CRC64;
MTNGQKRRRR MKKVASFICK HKLFIVLCSL FALIPAVLGM QATKINYDIL VYLPDDIETM
KGQDILTEDF NMGSFSTVIV DGMKPKEILA LEEEFKTIEG VEKAISVSDI TGTTFPIQML
PENIAEKVSK GDSQLMLVTF HDSISSDETL AAVEQMRSIT DKHCKIGGMS AMVLDTQQIA
DQEILIYIAA AVVLCLIVLM LSLDSWLAPL LLLGNIGLAI LYNMGTNYFL GEISYITKAI
SAVLQLGVTT DFSIFLYHKY EKSKQLYATN NEAMSAAIQE TTLSVAGSSF TTIAGFLTLC
TMSLTLGADI GLVMAKGVIF GIFSVLVIFP AYLLLFDPLL QKTAHVKWLP SISRISDFTV
KHYRKILLVF IILCVPALYG NANTEVYYNL NKSLPDDLSS SIANEELKET YHIVSPSIIL
VDDSLKPSEI EQLSKELNAL DGIDMTLSSA LFSEYGISES MLPQSIRSIY QNGDYQAILI
NSTYETATNE LNAQIDEVNK IVKRYDAHGI VAGEGALMKD MVEIADHDFQ VVNSISIAVI
LIIMIFVLKS FLLPIILVAV IEFAIMANMA ISFYLGTTLP FIASIVIGTI QLGATIDYAI
LLTNNYLNLR KSGVEKKQAV GDALKESCDS IFVSALCFFA ATCGVGFISK LDMIASICTL
LSRGAIISMG TVMIILPALL IVFDKIVLKT TKGFKGGKQA
//
