ID A8T7L2_HCMV Unreviewed; 214 AA.
AC A8T7L2;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=UL130 {ECO:0000313|EMBL:ABV71640.1, ECO:0000313|EMBL:ACT81953.1};
GN Name=UL130 {ECO:0000313|EMBL:ACT81953.1};
OS Human cytomegalovirus (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus;
OC Cytomegalovirus humanbeta5.
OX NCBI_TaxID=10359 {ECO:0000313|EMBL:ABV71640.1, ECO:0000313|Proteomes:UP000181190};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ADB84749.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5234 {ECO:0000313|EMBL:ADB84749.1};
RX PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W., Davison A.J.;
RT "Genetic content of wild-type human cytomegalovirus.";
RL J. Gen. Virol. 85:1301-1312(2004).
RN [2] {ECO:0000313|EMBL:AGQ47335.1, ECO:0000313|Proteomes:UP000143167}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TB40/E {ECO:0000313|EMBL:AGQ47335.1};
RX PubMed=15640804; DOI=10.1038/ni1156;
RA Tomasec P., Wang E.C., Davison A.J., Vojtesek B., Armstrong M., Griffin C.,
RA McSharry B.P., Morris R.J., Llewellyn-Lacey S., Rickards C., Nomoto A.,
RA Sinzger C., Wilkinson G.W.;
RT "Downregulation of natural killer cell-activating ligand CD155 by human
RT cytomegalovirus UL141.";
RL Nat. Immunol. 6:181-188(2005).
RN [3] {ECO:0000313|EMBL:ABV71640.1, ECO:0000313|Proteomes:UP000181190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TB40/E {ECO:0000313|EMBL:ABV71640.1};
RX PubMed=18198366; DOI=10.1099/vir.0.83286-0;
RA Sinzger C., Hahn G., Digel M., Katona R., Sampaio K.L., Messerle M.,
RA Hengel H., Koszinowski U., Brune W., Adler B.;
RT "Cloning and sequencing of a highly productive, endotheliotropic virus
RT strain derived from human cytomegalovirus TB40/E.";
RL J. Gen. Virol. 89:359-368(2008).
RN [4] {ECO:0000313|EMBL:ADB84749.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5234 {ECO:0000313|EMBL:ADB84749.1};
RA Davison A.J.;
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:ACT81953.1, ECO:0000313|Proteomes:UP000152877}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HAN20 {ECO:0000313|EMBL:ACT81953.1};
RX PubMed=19906940; DOI=10.1099/vir.0.015891-0;
RA Cunningham C., Gatherer D., Hilfrich B., Baluchova K., Dargan D.J.,
RA Thomson M., Griffiths P.D., Wilkinson G.W., Schulz T.F., Davison A.J.;
RT "Sequences of complete human cytomegalovirus genomes from infected cell
RT cultures and clinical specimens.";
RL J. Gen. Virol. 91:605-615(2010).
RN [6] {ECO:0000313|EMBL:ADE62325.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FIALA-B {ECO:0000313|EMBL:ADE62325.1}, and FIALA-F
RC {ECO:0000313|EMBL:ADE62328.1};
RA Hayward G.S., Zong J.-C.;
RT "Human Cytomegalovirus UL128, UL130 and UL131A Variability.";
RL Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|Proteomes:UP000142544, ECO:0000313|Proteomes:UP000164301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=66 {ECO:0000313|EMBL:ADB84653.1}, HAN12
RC {ECO:0000313|EMBL:AFR55601.1}, HAN16 {ECO:0000313|EMBL:AFR55770.1},
RC HAN22 {ECO:0000313|EMBL:AFR56104.1}, and TB40/E
RC {ECO:0000313|EMBL:AGQ47335.1};
RA Davison A.J.;
RT "Human cytomegalovirus RL11 gene family: variation, recombination and
RT transcription.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000113415, ECO:0000313|Proteomes:UP000132954}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BE/10/2010 {ECO:0000313|EMBL:AHB19587.1}, BE/27/2010
RC {ECO:0000313|EMBL:AHB20084.1}, and BE/9/2010
RC {ECO:0000313|EMBL:AHB19419.1};
RX PubMed=24755734;
RA Sijmons S., Thys K., Corthout M., Van Damme E., Van Loock M., Bollen S.,
RA Baguet S., Aerssens J., Van Ranst M., Maes P.;
RT "A method enabling high-throughput sequencing of human cytomegalovirus
RT complete genomes from clinical isolates.";
RL PLoS ONE 9:E95501-E95501(2014).
RN [9] {ECO:0000313|Proteomes:UP000099255, ECO:0000313|Proteomes:UP000105582}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BE/1/2012 {ECO:0000313|EMBL:AKI18696.1}, BE/12/2010
RC {ECO:0000313|EMBL:AKI17860.1}, BE/17/2011
RC {ECO:0000313|EMBL:AKI17023.1}, BE/18/2011
RC {ECO:0000313|EMBL:AKI13515.1}, BE/2/2012
RC {ECO:0000313|EMBL:AKI20538.1}, BE/23/2011
RC {ECO:0000313|EMBL:AKI14688.1}, BE/25/2010
RC {ECO:0000313|EMBL:AKI15190.1}, BE/27/2011
RC {ECO:0000313|EMBL:AKI18193.1}, BE/28/2010
RC {ECO:0000313|EMBL:AKI14855.1}, BE/28/2011
RC {ECO:0000313|EMBL:AKI13683.1}, BE/32/2011
RC {ECO:0000313|EMBL:AKI19535.1}, BE/38/2011
RC {ECO:0000313|EMBL:AKI19700.1}, BE/42/2011
RC {ECO:0000313|EMBL:AKI14351.1}, BE/43/2011
RC {ECO:0000313|EMBL:AKI15692.1}, BE/5/2011
RC {ECO:0000313|EMBL:AKI13346.1}, BE/5/2012
RC {ECO:0000313|EMBL:AKI07999.1}, and BE/6/2011
RC {ECO:0000313|EMBL:AKI12181.1};
RX PubMed=25972543;
RA Sijmons S., Thys K., Mbong Ngwese M., Van Damme E., Dvorak J.,
RA Van Loock M., Li G., Tachezy R., Busson L., Aerssens J., Van Ranst M.,
RA Maes P.;
RT "High-throughput analysis of human cytomegalovirus genome diversity
RT highlights the widespread occurrence of gene-disrupting mutations and
RT pervasive recombination.";
RL J. Virol. 89:7673-7695(2015).
RN [10] {ECO:0000313|EMBL:AMJ52977.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NL/Rot3/Nasal/2012 {ECO:0000313|EMBL:AMJ52977.1};
RA Lassalle F., Depledge D.P., Reeves M.B., Brown A.C., Christiansen M.T.,
RA Tutill H.J., Williams R.J., Einer-Jensen K., Holdstock J., Atkinson C.,
RA Brown J.R., van Loenen F.B., Clark D.A., Griffiths P.D., Verjans G.M.G.M.,
RA Schutten M., Milne R.S.B., Balloux F., Breuer J.;
RT "Islands of linkage in an ocean of pervasive recombination reveals two-
RT speed evolution of human cytomegalovirus genomes.";
RL Virus Evol. 2:vew017-vew017(2016).
RN [11] {ECO:0000313|EMBL:AMJ52977.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NL/Rot3/Nasal/2012 {ECO:0000313|EMBL:AMJ52977.1};
RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.;
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:VDY02661.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PAT_F_1 {ECO:0000313|EMBL:VDY02661.1};
RA Camiolo S.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; EF999921; ABV71640.1; -; Genomic_DNA.
DR EMBL; GQ396663; ACT81953.1; -; Genomic_DNA.
DR EMBL; GQ222010; ADB84653.1; -; Genomic_DNA.
DR EMBL; GQ222014; ADB84749.1; -; Genomic_DNA.
DR EMBL; GU574784; ADE62325.1; -; Genomic_DNA.
DR EMBL; GU574785; ADE62328.1; -; Genomic_DNA.
DR EMBL; JX512203; AFR55601.1; -; Genomic_DNA.
DR EMBL; JX512204; AFR55770.1; -; Genomic_DNA.
DR EMBL; JX512206; AFR56104.1; -; Genomic_DNA.
DR EMBL; KF297339; AGQ47335.1; -; Genomic_DNA.
DR EMBL; KC519319; AHB19419.1; -; Genomic_DNA.
DR EMBL; KC519320; AHB19587.1; -; Genomic_DNA.
DR EMBL; KC519323; AHB20084.1; -; Genomic_DNA.
DR EMBL; KP745635; AKI07999.1; -; Genomic_DNA.
DR EMBL; KP745660; AKI12181.1; -; Genomic_DNA.
DR EMBL; KP745667; AKI13346.1; -; Genomic_DNA.
DR EMBL; KP745668; AKI13515.1; -; Genomic_DNA.
DR EMBL; KP745669; AKI13683.1; -; Genomic_DNA.
DR EMBL; KP745673; AKI14351.1; -; Genomic_DNA.
DR EMBL; KP745675; AKI14688.1; -; Genomic_DNA.
DR EMBL; KP745676; AKI14855.1; -; Genomic_DNA.
DR EMBL; KP745678; AKI15190.1; -; Genomic_DNA.
DR EMBL; KP745681; AKI15692.1; -; Genomic_DNA.
DR EMBL; KP745689; AKI17023.1; -; Genomic_DNA.
DR EMBL; KP745694; AKI17860.1; -; Genomic_DNA.
DR EMBL; KP745696; AKI18193.1; -; Genomic_DNA.
DR EMBL; KP745699; AKI18696.1; -; Genomic_DNA.
DR EMBL; KP745704; AKI19535.1; -; Genomic_DNA.
DR EMBL; KP745705; AKI19700.1; -; Genomic_DNA.
DR EMBL; KP745710; AKI20538.1; -; Genomic_DNA.
DR EMBL; KT726942; AMJ52977.1; -; Genomic_DNA.
DR EMBL; LR131943; VDY02661.1; -; Genomic_DNA.
DR Proteomes; UP000099255; Genome.
DR Proteomes; UP000105582; Genome.
DR Proteomes; UP000106410; Genome.
DR Proteomes; UP000113415; Genome.
DR Proteomes; UP000122942; Genome.
DR Proteomes; UP000129533; Genome.
DR Proteomes; UP000132954; Genome.
DR Proteomes; UP000139167; Genome.
DR Proteomes; UP000139224; Genome.
DR Proteomes; UP000139295; Genome.
DR Proteomes; UP000142544; Genome.
DR Proteomes; UP000143167; Genome.
DR Proteomes; UP000144308; Genome.
DR Proteomes; UP000146391; Genome.
DR Proteomes; UP000151533; Genome.
DR Proteomes; UP000152877; Genome.
DR Proteomes; UP000154402; Genome.
DR Proteomes; UP000157654; Genome.
DR Proteomes; UP000158879; Genome.
DR Proteomes; UP000164042; Genome.
DR Proteomes; UP000164301; Genome.
DR Proteomes; UP000164574; Genome.
DR Proteomes; UP000167502; Genome.
DR Proteomes; UP000169355; Genome.
DR Proteomes; UP000172109; Genome.
DR Proteomes; UP000181190; Genome.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR InterPro; IPR021038; Herpes_UL130_cytomegalovirus.
DR Pfam; PF11668; Gp_UL130; 1.
PE 4: Predicted;
KW Viral envelope protein {ECO:0000313|EMBL:ACT81953.1};
KW Virion {ECO:0000313|EMBL:ACT81953.1}.
SQ SEQUENCE 214 AA; 24751 MW; C7E0A12E2C834ED8 CRC64;
MLRLLLRHHF HCLLLCAVWA TPCLASPWST LTANQNPSPL WSKLTYSKPH DAATFYCPFI
YPSPPRSPLQ FSGFQRVLTG PECRNETLYL LYNREGQTLV ERSSTWVKKV IWYLSGRNQT
ILQRMPRTAS KPSDGNVQIS VEDAKIFGAH MVPKQTKLLR FVVNDGTRYQ MCVMKLESWA
HVFRDYSVSF QVRLTFTEAN NQTYTFCTHP NLIV
//
