ID   A8TMS1_9PROT            Unreviewed;       515 AA.
AC   A8TMS1;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN   ORFNames=BAL199_03554 {ECO:0000313|EMBL:EDP65869.1};
OS   alpha proteobacterium BAL199.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria.
OX   NCBI_TaxID=331869 {ECO:0000313|EMBL:EDP65869.1, ECO:0000313|Proteomes:UP000003417};
RN   [1] {ECO:0000313|EMBL:EDP65869.1, ECO:0000313|Proteomes:UP000003417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BAL199 {ECO:0000313|EMBL:EDP65869.1,
RC   ECO:0000313|Proteomes:UP000003417};
RA   Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA   Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDP65869.1}.
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DR   EMBL; ABHC01000003; EDP65869.1; -; Genomic_DNA.
DR   AlphaFoldDB; A8TMS1; -.
DR   STRING; 331869.BAL199_03554; -.
DR   eggNOG; COG0028; Bacteria.
DR   OrthoDB; 9773408at2; -.
DR   Proteomes; UP000003417; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd02002; TPP_BFDC; 1.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF86; ACETOLACTATE SYNTHASE LARGE SUBUNIT ILVX-RELATED; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003417}.
FT   DOMAIN          473..515
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   515 AA;  53622 MW;  2384B94993395D2E CRC64;
     MNGAESLVRT LVASGVDVCF TNPGTSEMHF VAALDRVDGM RCVLGLFEGV VTGMADGYGR
     MADKPASTLL HLGPGLGNGI ANLHNAKKGF TPIVNIVGEH ATYHIKYDAP LTSDIEGIAR
     PVSGWVKTST DAKDVAGDGA AAVAASMGPP GQIATLILPA NTAWDESNGP AAPVAPTPLP
     GPDADAVREA AKALKAGGKA LLHMTGRSLR ADTLEIAGRI AAKTGCRLSC QTSNGRWQRG
     AGRVSIERIQ YPVDIALKQL ASVEQLVLLG TKAPVAFFAY PNKPSLLTPE GCAVHTLAEI
     GDDHLAVLTA LCDELDAWNA KPVLQQAERP ELATGALTPE AVAAALGRLM PENAIIADES
     VTSGRGFMPY TAGSAPHDWL SLTGGAIGLG LPYATGAAIA CPDRKVICTE GDGSGMYTLQ
     ALWTQAREGC DVVNIIFANR SYAILRHELT NVGAQNPGRK AIDMLTLDRP ELDWVALAKG
     MGVAGVRVDT AEAFNDALAR AIAEPGPHLI EAWMA
//