ID A8TS50_9PROT Unreviewed; 609 AA.
AC A8TS50;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=O-acetylhomoserine/O-acetylserine sulfhydrylase {ECO:0000313|EMBL:EDP64476.1};
GN ORFNames=BAL199_27001 {ECO:0000313|EMBL:EDP64476.1};
OS alpha proteobacterium BAL199.
OC Bacteria; Pseudomonadota; Alphaproteobacteria.
OX NCBI_TaxID=331869 {ECO:0000313|EMBL:EDP64476.1, ECO:0000313|Proteomes:UP000003417};
RN [1] {ECO:0000313|EMBL:EDP64476.1, ECO:0000313|Proteomes:UP000003417}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BAL199 {ECO:0000313|EMBL:EDP64476.1,
RC ECO:0000313|Proteomes:UP000003417};
RA Hagstrom A., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDP64476.1}.
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DR EMBL; ABHC01000008; EDP64476.1; -; Genomic_DNA.
DR AlphaFoldDB; A8TS50; -.
DR STRING; 331869.BAL199_27001; -.
DR eggNOG; COG2873; Bacteria.
DR OrthoDB; 9790858at2; -.
DR Proteomes; UP000003417; Unassembled WGS sequence.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR003781; CoA-bd.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF13380; CoA_binding_2; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR SMART; SM00881; CoA_binding; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000003417}.
FT DOMAIN 24..120
FT /note="CoA-binding"
FT /evidence="ECO:0000259|SMART:SM00881"
SQ SEQUENCE 609 AA; 65800 MW; 4C1FB64CC1BA389E CRC64;
MAEIDPTRAV VHDAYSDDYI RDILRNVKTI AMVGASDNWN RPSYFAMKYL QQKGYRVFPV
NPKVAAAGGE ILGEKAYADL KDLPETADMV DVFRNSAAAG PVTDAAIEHG TKVVWMQLGV
RNDEAAERAE KAGIQVVMNR CPKIEFSRLF GELGWHGFNS RVISSKRRTP GSSDAVKGDS
DVGDGFIAKG FETLAVHAGA APDPTTGARA TPIYQTTAYV FDDVDHAASL FNLQTFGNIY
SRLSNPTVAV LEERIAALEG GHGTTCTASG HSAQLLALFA LMGPGDRFVA STRLYGGSIT
QFGRTFKKFD WHCDFVDVED LDATRQAALH PKCKAIFAES LANPGGVITD MQALARIADE
AGVPLIIDNT MATPYLCRPF EHGADIVVHS TTKFLSGHGN AMGGAVVDGG KFDWSKNDKF
PSLSQPEPAY HGLTFFETFG DLAYTIYGHA VGLRDLGPTM APMNAYLTIT GIETLALRME
RHVANAQKIA EWLNAHPKVA WVSYAGLPGN RYHELANRYL PKGAGSVFTF GVVGGYQAGV
RAVERCRLLS HLANIGDTRS LILHPASTTH RQLTDEQRTT AGAGDDVIRL SIGLESAEDI
MADLDRALG
//
