ID A8WG25_DANRE Unreviewed; 546 AA.
AC A8WG25; A0A8M1RN79; X1WH46;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=FinTRIM family, member 11 {ECO:0000313|Ensembl:ENSDARP00000017772};
DE SubName: Full=Si:ch211-220f13.2 protein {ECO:0000313|EMBL:AAI54554.1};
DE SubName: Full=Tripartite motif-containing protein 16 {ECO:0000313|RefSeq:XP_003197971.1, ECO:0000313|RefSeq:XP_021326953.1};
GN Name=ftr11 {ECO:0000313|Ensembl:ENSDARP00000017772,
GN ECO:0000313|RefSeq:XP_003197971.1, ECO:0000313|RefSeq:XP_021326953.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070912-195};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI54554.1};
RN [1] {ECO:0000313|EMBL:AAI54554.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAI54554.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSDARP00000017772}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000017772};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000017772, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000017772};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000129556}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129556};
RG Ensembl;
RL Submitted (MAR-2014) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:XP_003197971.1, ECO:0000313|RefSeq:XP_021326953.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_003197971.1,
RC ECO:0000313|RefSeq:XP_021326953.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX005083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC154553; AAI54554.1; -; mRNA.
DR RefSeq; XP_003197971.1; XM_003197923.4.
DR RefSeq; XP_021326953.1; XM_021471278.1.
DR PaxDb; 7955-ENSDARP00000017772; -.
DR Ensembl; ENSDART00000005767.8; ENSDARP00000017772.6; ENSDARG00000038646.7.
DR Ensembl; ENSDART00000154422.3; ENSDARP00000129556.3; ENSDARG00000115336.1.
DR GeneID; 569723; -.
DR KEGG; dre:569723; -.
DR AGR; ZFIN:ZDB-GENE-070912-195; -.
DR CTD; 569723; -.
DR ZFIN; ZDB-GENE-070912-195; ftr11.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_013137_0_2_1; -.
DR OMA; QLNANIC; -.
DR OrthoDB; 3938683at2759; -.
DR TreeFam; TF351086; -.
DR Proteomes; UP000000437; Chromosome 2.
DR Bgee; ENSDARG00000038646; Expressed in intestine and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF36; E3 UBIQUITIN-PROTEIN LIGASE TRIML1-RELATED; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 15..58
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 139..179
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 355..546
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 201..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 252..286
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 546 AA; 63141 MW; 01E2DCBA1577DFAE CRC64;
MAESSVCLAQ EQFSCSICLD LLKDSVAIPC GHSYCMSCIS DCWDQDERKG VYSCPQCRQS
FTPRPALGKN TMLTEVMENI RKRKLQAGDV ECDVCTGRKF KAVKSCLVCL ESYCQTHFQR
HEEFHSRKRH KVTDATGRLQ EMICPLHEKL LEIFCRTDQC CICYLCTMDK HKNHDTVSAA
AEWTDKKIQL AEMQKTTHQR MVERQKEREE LRAAVESHKR SAQAAVEDTE SIFTELIFSF
ERSCSEVTQL ITDQQKAAEG RAEERLKQLE QEIDDLRRRN TELEQLSHTD HHIHFLKSFQ
SLSSPPGSTD SSSITVSSRI SFDDVGKLSH LRKKLEHFCR EEIEKISSKV RDINIISISA
EPKTRQEFLQ YSRQLTFDPN TVNTSLVLSK KNRVIEYTDK VQQYPDHPDR FDCWPQVLCR
ESECGRFYWE VEWNGYIEIS VSYKSISRKG RGNECVFGCN DQSWSLFCSR SRFSFRHNKQ
QTKLPVLSIS SRIGVYVDHS AGTLSFYNVS DTMSLIYRVH TTFTQPLYPG FWVFAGSILF
TTDTVI
//
