ID A8WGA6_DANRE Unreviewed; 284 AA.
AC A8WGA6; A0A8M1NGK1;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Tnnt3b protein {ECO:0000313|EMBL:AAI54639.1};
DE SubName: Full=Troponin T type 3b (skeletal, fast) {ECO:0000313|Ensembl:ENSDARP00000035181};
DE SubName: Full=Troponin T, fast skeletal muscle isoform 1 {ECO:0000313|RefSeq:NP_001103886.1};
GN Name=tnnt3b {ECO:0000313|EMBL:AAI54639.1,
GN ECO:0000313|Ensembl:ENSDARP00000035181,
GN ECO:0000313|RefSeq:NP_001103886.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030520-2};
GN Synonyms=b44 {ECO:0000313|RefSeq:NP_001103886.1}, cb44
GN {ECO:0000313|RefSeq:NP_001103886.1}, sb:cb44
GN {ECO:0000313|RefSeq:NP_001103886.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI54639.1};
RN [1] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12761854; DOI=10.1002/dvdy.10305;
RA Hsiao C.D., Tsai W.Y., Horng L.S., Tsai H.J.;
RT "Molecular structure and developmental expression of three muscle-type
RT troponin T genes in zebrafish.";
RL Dev. Dyn. 227:266-279(2003).
RN [2] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18248185;
RA Leung Y.F., Dowling J.E.;
RT "Gene expression profiling of zebrafish embryonic retina.";
RL Zebrafish 2:269-283(2005).
RN [3] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16942865;
RA Wang Y., Qian L., Dong Y., Jiang Q., Gui Y., Zhong T.P., Song H.;
RT "Myocyte-specific enhancer factor 2A is essential for zebrafish posterior
RT somite development.";
RL Mech. Dev. 123:783-791(2006).
RN [4] {ECO:0000313|EMBL:AAI54639.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole body {ECO:0000313|EMBL:AAI54639.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18297736;
RA Wang Y.H., Li C.K., Lee G.H., Tsay H.J., Tsai H.J., Chen Y.H.;
RT "Inactivation of zebrafish mrf4 leads to myofibril misalignment and motor
RT axon growth disorganization.";
RL Dev. Dyn. 237:1043-1050(2008).
RN [6] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18253507; DOI=10.1371/journal.pone.0001567;
RA Macqueen D.J., Johnston I.A.;
RT "An update on MyoD evolution in teleosts and a proposed consensus
RT nomenclature to accommodate the tetraploidization of different vertebrate
RT genomes.";
RL PLoS ONE 3:e1567-e1567(2008).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000035181}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000035181};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [8] {ECO:0000313|Ensembl:ENSDARP00000035181, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000035181};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [9] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [10] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [11] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26827899;
RA Gomes R.S., Skroblin P., Munster A.B., Tomlins H., Langley S.R.,
RA Zampetaki A., Yin X., Wardle F.C., Mayr M.;
RT "'Young at heart': Regenerative potential linked to immature cardiac
RT phenotypes.";
RL J. Mol. Cell. Cardiol. 92:105-108(2016).
RN [12] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29751158;
RA Arcanjo C., Armant O., Floriani M., Cavalie I., Camilleri V., Simon O.,
RA Orjollet D., Adam-Guillermin C., Gagnaire B.;
RT "Tritiated water exposure disrupts myofibril structure and induces mis-
RT regulation of eye opacity and DNA repair genes in zebrafish early life
RT stages.";
RL Aquat. Toxicol. 200:114-126(2018).
RN [13] {ECO:0000313|RefSeq:NP_001103886.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29483630;
RA Kwon O.K., Kim S.J., Lee S.;
RT "First profiling of lysine crotonylation of myofilament proteins and
RT ribosomal proteins in zebrafish embryos.";
RL Sci. Rep. 8:3652-3652(2018).
RN [14] {ECO:0000313|RefSeq:NP_001103886.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Troponin T is the tropomyosin-binding subunit of troponin,
CC the thin filament regulatory complex which confers calcium-sensitivity
CC to striated muscle actomyosin ATPase activity.
CC {ECO:0000256|ARBA:ARBA00003363}.
CC -!- SIMILARITY: Belongs to the troponin T family.
CC {ECO:0000256|ARBA:ARBA00008330}.
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DR EMBL; BX842701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC154638; AAI54639.1; -; mRNA.
DR RefSeq; NP_001103886.1; NM_001110416.1.
DR STRING; 7955.ENSDARP00000121128; -.
DR Ensembl; ENSDART00000033610.7; ENSDARP00000035181.6; ENSDARG00000068457.7.
DR Ensembl; ENSDART00000142946.4; ENSDARP00000121128.1; ENSDARG00000068457.7.
DR GeneID; 100003572; -.
DR KEGG; dre:100003572; -.
DR AGR; ZFIN:ZDB-GENE-030520-2; -.
DR CTD; 100003572; -.
DR ZFIN; ZDB-GENE-030520-2; tnnt3b.
DR eggNOG; KOG3634; Eukaryota.
DR OMA; EEXLTAP; -.
DR OrthoDB; 5362548at2759; -.
DR Reactome; R-DRE-390522; Striated Muscle Contraction.
DR Proteomes; UP000000437; Chromosome 7.
DR Bgee; ENSDARG00000068457; Expressed in bone element and 33 other cell types or tissues.
DR GO; GO:0005861; C:troponin complex; IBA:GO_Central.
DR GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR GO; GO:0030172; F:troponin C binding; IBA:GO_Central.
DR GO; GO:0031013; F:troponin I binding; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR GO; GO:0030239; P:myofibril assembly; IMP:ZFIN.
DR GO; GO:0006937; P:regulation of muscle contraction; IEA:InterPro.
DR GO; GO:0045214; P:sarcomere organization; IMP:ZFIN.
DR Gene3D; 1.20.5.350; -; 1.
DR InterPro; IPR027707; TNNT.
DR InterPro; IPR001978; Troponin.
DR InterPro; IPR038077; Troponin_sf.
DR PANTHER; PTHR11521; TROPONIN T; 1.
DR PANTHER; PTHR11521:SF4; TROPONIN T, FAST SKELETAL MUSCLE; 1.
DR Pfam; PF00992; Troponin; 1.
DR SUPFAM; SSF90250; Troponin coil-coiled subunits; 1.
PE 1: Evidence at protein level;
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A8WGA6};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..41
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 284 AA; 33599 MW; E5CF77DBED81C153 CRC64;
MSDTEDVGVE EVVEVEVAPE AAPEPEPEPE PEQEPVPEPE PEPEPEPEKQ PEPEPEPEPE
QEVHEEEEKP KFKPSAPKIP DGDKVDFDDI QKKRQNKDLV ELQALIDAHF EHRKKEEEEL
IALKDRIEKR RSERAEQQRI RAEKDKERQA RREEERLRKE EADAKKRADE DAKKKSALSN
MGSQYSSYLQ KADSKRGGKK QTEREKKKKI LAERRKPLNI DHMNEDKLRE KAKELWDWLY
SLEAEKFEHM EKLKRQKYEV TTQRKRVEEL SKYSKKGAAA RRRK
//
