ID   A8WLE8_CAEBR            Unreviewed;       616 AA.
AC   A8WLE8;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 2.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Protein CBG24757 {ECO:0000313|EMBL:CAP21293.2};
GN   ORFNames=CBG24757 {ECO:0000313|EMBL:CAP21293.2,
GN   ECO:0000313|WormBase:CBG24757}, CBG_24757
GN   {ECO:0000313|EMBL:CAP21293.2};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP21293.2, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP21293.2, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP21293.2,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE601269; CAP21293.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WLE8; -.
DR   STRING; 6238.A8WLE8; -.
DR   WormBase; CBG24757; CBP43335; WBGene00042796; -.
DR   eggNOG; KOG1132; Eukaryota.
DR   HOGENOM; CLU_530223_0_0_1; -.
DR   InParanoid; A8WLE8; -.
DR   OMA; AFDSHIN; -.
DR   OrthoDB; 124793at2759; -.
DR   Proteomes; UP000008549; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0003678; F:DNA helicase activity; IBA:GO_Central.
DR   GO; GO:0070182; F:DNA polymerase binding; IBA:GO_Central.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0032508; P:DNA duplex unwinding; IBA:GO_Central.
DR   GO; GO:0045910; P:negative regulation of DNA recombination; IBA:GO_Central.
DR   GO; GO:1904430; P:negative regulation of t-circle formation; IBA:GO_Central.
DR   GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0090657; P:telomeric loop disassembly; IBA:GO_Central.
DR   CDD; cd18788; SF2_C_XPD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR045028; DinG/Rad3-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013020; Rad3/Chl1-like.
DR   NCBIfam; TIGR00604; rad3; 1.
DR   PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR   PANTHER; PTHR11472:SF34; REGULATOR OF TELOMERE ELONGATION HELICASE 1; 1.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT   DOMAIN          166..341
FT                   /note="ATP-dependent helicase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00491"
FT   REGION          440..518
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   616 AA;  70461 MW;  AA91BCFA08A43334 CRC64;
     MKTSSSSLIK IVSWCQRTRE LSGFNVSHLQ LADRVDPATV ARNCKLYIRK DSGKLVIKYF
     CFQASISMRM LKMRGVRNVL LASGTLSPIQ AFTYNMGLNF GAILENEHAL KQVPVLTSIV
     TRGKHGGLVG SFQNRKNIEY VSDVGESLIR VMETTPQGVL VFFSSYSQMD ELVEVWKKTK
     RGASDSPETF WEKMEKTKKI AVEPRAKEQL AAVRLRYTQG VSEPHGAALL AVCRGKVSEG
     IDFCDAESRA VIIVGIPYPP IHDERVVLKK MYLDDLMGRK DLVRVFNFFS ENLNFQTNEP
     QSSRDWYQME AFRAVNQAIG RVLRHKNDFG TVVLIDTRYA SAKPEMFPKW LRNTISRCDS
     NNCALKTARF FKERGHLIEV IFIFYKITNL MFQNSKSEYI KKQAKTCKSF RQVKSQSASN
     PKDDITDITL EDMFSPANMK IEKKEKIEPR PIKYDSSSSS VFSLPTNEDE LKVKKWEQEN
     DSQTNVSSSS DLNKRKYKAE TPGNSSGQHV VSGSEPPKKR KMVLLTRETL PEKYQNALNI
     PTSELTKGMS LDNQKQFVAT LKGYKATNME WQEVFQRLHQ IFIPDRPDLF ISCSNILRSE
     DKMKYIRRSL GMKINY
//