ID A8WNB0_CAEBR Unreviewed; 598 AA.
AC A8WNB0;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Protein CBR-EFL-3 {ECO:0000313|EMBL:CAP21964.2};
GN Name=efl-3 {ECO:0000313|WormBase:CBG00680};
GN Synonyms=Cbr-efl-3 {ECO:0000313|EMBL:CAP21964.2};
GN ORFNames=CBG00680 {ECO:0000313|WormBase:CBG00680}, CBG_00680
GN {ECO:0000313|EMBL:CAP21964.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP21964.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP21964.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP21964.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU003796}.
CC -!- SIMILARITY: Belongs to the E2F/DP family.
CC {ECO:0000256|ARBA:ARBA00010940, ECO:0000256|RuleBase:RU003796}.
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DR EMBL; HE600999; CAP21964.2; -; Genomic_DNA.
DR RefSeq; XP_002630258.1; XM_002630212.1.
DR AlphaFoldDB; A8WNB0; -.
DR STRING; 6238.A8WNB0; -.
DR GeneID; 8571773; -.
DR WormBase; CBG00680; CBP20827; WBGene00024037; Cbr-efl-3.
DR eggNOG; KOG2578; Eukaryota.
DR HOGENOM; CLU_462503_0_0_1; -.
DR InParanoid; A8WNB0; -.
DR OMA; KSYYQWQ; -.
DR OrthoDB; 1761at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR015633; E2F.
DR InterPro; IPR003316; E2F_WHTH_DNA-bd_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR12081; TRANSCRIPTION FACTOR E2F; 1.
DR PANTHER; PTHR12081:SF7; TRANSCRIPTION FACTOR EFL-3; 1.
DR Pfam; PF02319; E2F_TDP; 2.
DR SMART; SM01372; E2F_TDP; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003796};
KW Nucleus {ECO:0000256|RuleBase:RU003796};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU003796};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU003796}.
FT DOMAIN 98..167
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT DOMAIN 253..340
FT /note="E2F/DP family winged-helix DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01372"
FT REGION 18..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 598 AA; 66744 MW; AAFDC973DA3599E7 CRC64;
MTANVYGSSN AIFLTIEANK ENIPPGTEID IKKEESFLLP EPRGNRPADP DTESLTASPV
PRPSPATSQL SDASFLSQDP TVTNSADESE DDPEFTSRKE KSLGLLCQRF LISINEETQE
SPTKEVHLET VARKMCVEKR RIYDIVNVME ALDAMHKTNK SYYQWQGLES LPRLMADLQA
EAIEEGLPDR VLRVEQAMCS FTELQSPRGN KGIKDTVGSF VSGSSAPTTP TTSFEPRRTE
TEKRSRVDSR DRQGRNSLAQ LCRRFLMVLL SNPKNVRKVS LDVASTVLIK DPETEGFEPP
SRSRCRRLYD IANVLVALGL IKKVHYLFGT KKIPLFVYCG PEPDEHASFD VFQSVERLLS
SPQNVPQTPV IKAQTDKMVQ QIAGFGKRTL SEQNLSKPIG NSPKIAKIKS EMSPMTVPVS
PMADENRLFM FAELAAAQKM QEDLAQLSRS LMQRVNTPMA PMTAPISSPM VGSAPPPLPM
APLNLSGLGK LPPLVFPPTQ LPNLPNTRPK FNFPDYNPTQ STIRPLVSQM TFRPELFENN
PIPPPQPPKH LMSNILGESK SFKNMQNTNN NNFFDHNTKS SAFHVVVKKD EQQQRRTK
//
