ID A8WRA1_CAEBR Unreviewed; 420 AA.
AC A8WRA1;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Major sperm protein {ECO:0000256|RuleBase:RU003425};
GN ORFNames=CBG01600 {ECO:0000313|EMBL:CAP23009.1,
GN ECO:0000313|WormBase:CBG01600}, CBG_01600
GN {ECO:0000313|EMBL:CAP23009.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23009.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP23009.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP23009.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Central component in molecular interactions underlying sperm
CC crawling. Forms an extensive filament system that extends from sperm
CC villipoda, along the leading edge of the pseudopod.
CC {ECO:0000256|ARBA:ARBA00037744, ECO:0000256|RuleBase:RU003425}.
CC -!- SUBCELLULAR LOCATION: Cell projection, pseudopodium
CC {ECO:0000256|ARBA:ARBA00037818}. Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; HE601298; CAP23009.1; -; Genomic_DNA.
DR RefSeq; XP_002634058.1; XM_002634012.1.
DR AlphaFoldDB; A8WRA1; -.
DR STRING; 6238.A8WRA1; -.
DR EnsemblMetazoa; CBG01600.1; CBG01600.1; WBGene00024814.
DR GeneID; 8576053; -.
DR KEGG; cbr:CBG_01600; -.
DR CTD; 8576053; -.
DR WormBase; CBG01600; CBP06114; WBGene00024814; -.
DR eggNOG; ENOG502S47Y; Eukaryota.
DR HOGENOM; CLU_781248_0_0_1; -.
DR InParanoid; A8WRA1; -.
DR OMA; LERIPCY; -.
DR OrthoDB; 2881487at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR PANTHER; PTHR22920; MAJOR SPERM PROTEIN; 1.
DR PANTHER; PTHR22920:SF21; MAJOR SPERM PROTEIN; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SUPFAM; SSF49354; PapD-like; 1.
DR PROSITE; PS50202; MSP; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|RuleBase:RU003425}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 300..419
FT /note="MSP"
FT /evidence="ECO:0000259|PROSITE:PS50202"
FT REGION 147..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..247
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 46971 MW; 60808909383A051B CRC64;
MSDSCGDKCE TLEWLRERIH NKKHFTARFI GQIADASGMD AELIVKIFGG VLFVILVFSD
HAHFFANQLL VLVPALLIFV FPAEKPTDDS LFIYFSLFGA LTVMDRSLER IPCYYIFKLA
LFVLLYVPPY ELHKRISELI QEQLKKQKSN ENVSEISRSQ RTTPKTNQST RTALPPPPPQ
PVQEQPKPVE QAPASAPEPV PVPVPVEQPP PPPPVEQAPP PPAPAPAPVA EAPQAQQEPP
APADPEPKLP SSRSHSDLAG GSQRLKSGPN PMQSNSFYNL RSESNGFNSR AISPAGNLND
MMFLPTGKLV FNAPFDYDNL TYHMKITNNS RHRIAYAVKG NAVPRVMANP AFGILNVEEM
RIVAVSVQKF AWNDVDFQKD RIAFDYVLLP DDNKENTFQM SMFQQSDSKI RKNIKIEYNP
//
