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Database: UniProt
Entry: A8WRW6_CAEBR
LinkDB: A8WRW6_CAEBR
Original site: A8WRW6_CAEBR 
ID   A8WRW6_CAEBR            Unreviewed;      1536 AA.
AC   A8WRW6;
DT   15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT   15-JAN-2008, sequence version 1.
DT   28-MAR-2018, entry version 86.
DE   SubName: Full=Protein CBR-UNC-2 {ECO:0000313|EMBL:CAP23224.1};
DE   Flags: Fragment;
GN   Name=unc-2 {ECO:0000313|WormBase:CBG02059a};
GN   Synonyms=Cbr-unc-2 {ECO:0000313|EMBL:CAP23224.1};
GN   ORFNames=CBG02059 {ECO:0000313|WormBase:CBG02059a}, CBG_02059
GN   {ECO:0000313|EMBL:CAP23224.1};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23224.1, ECO:0000313|Proteomes:UP000008549};
RN   [1] {ECO:0000313|EMBL:CAP23224.1, ECO:0000313|Proteomes:UP000008549}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000313|EMBL:CAP23224.1,
RC   ECO:0000313|Proteomes:UP000008549};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A.,
RA   D'Eustachio P., Fitch D.H., Fulton L.A., Fulton R.E.,
RA   Griffiths-Jones S., Harris T.W., Hillier L.W., Kamath R.,
RA   Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P.,
RA   Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M.,
RA   Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.,
RA   Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for
RT   comparative genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; HE601451; CAP23224.1; -; Genomic_DNA.
DR   RefSeq; XP_002643835.1; XM_002643789.1.
DR   STRING; 6238.CBG02059; -.
DR   GeneID; 8585828; -.
DR   KEGG; cbr:CBG02059; -.
DR   CTD; 8585828; -.
DR   WormBase; CBG02059a; CBP41938; WBGene00025194; Cbr-unc-2.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   HOGENOM; HOG000231529; -.
DR   InParanoid; A8WRW6; -.
DR   OMA; KDCRGQY; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008549};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     23     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     55     78       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    205    226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    238    260       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    390    411       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    423    442       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    515    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    610    632       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    871    893       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    984   1010       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1066   1084       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1096   1119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1131   1156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1176   1205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1281   1304       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1320   1355       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      268    288       {ECO:0000256|SAM:Coils}.
FT   COILED      316    362       {ECO:0000256|SAM:Coils}.
FT   COILED      637    667       {ECO:0000256|SAM:Coils}.
FT   NON_TER    1536   1536       {ECO:0000313|EMBL:CAP23224.1}.
SQ   SEQUENCE   1536 AA;  176498 MW;  6C093E28794D2432 CRC64;
     MEQHLPKNDK KALSEWLERT EPYFMGIFCL ECILKVIAFG FAFHKGSYLR SGWNIMDFIV
     VVSGVVTMLP FGSTIQAANQ PVDTVDLRTL RAVRVLRPLK LVSGIPSLQV VLKSILCAMA
     PLLQIGLLVL FAIIIFAIIG LEFYSGAFHS ACYNERGEIE NVSEKPMPCT NKTSPMGVYN
     CDVKGTTCLQ KWIGPNYGIT SFDNIGFAMI TVFQCITMEG WTTVMYYTND SLGSTYNWAY
     FIPLIVLGSF FMLNLVLGVL SGEFAKERER VENRREFLKL RRQQQIEREL NGYLEWILTA
     EEVILKEDRT TEEEKAAIME ARRRAANKKL KQASKQQSTE TEEDFEEDED EMEEEYVDEA
     ERKKRGCCHS LGKFIKQLRI QIRIMVKTQI FYWSVITLVF LNTCCVASEH YGQPQWFTDF
     LKYAEFVFLG IFVVEMLLKL FAMGSRTYFA SKFNRFDCVV IVGSAAEVIW AEVYGGSFGI
     SVMRALRLLR IFKLTSYWVS LRNLVRSLMN SMRSIISLLF LLFLFILIFA LLGMQLFGGR
     FNFPTMHPYT HFDTFPVALI TVFQVSSINC HRNFELKFFK ILTGEDWNEV MYLAIESQGG
     IYSGGWPYSI YFIVLVLFGN YTLLNVFLAI AVDNLANAQE LTAAEEADEK ANEIEEESEE
     VDEQFQEGDH CTIDMEGKTA GDMCAVARAM DEMDEECEEE ESPFGGPKPM VPYSSMFFLS
     PTNPFRVLIH SIVCTKYFEM MVMTVICLSS VSLAAEDPVD EENPRNKVLQ YMDYCFTGVF
     ACEMLLKLID QGILLHPGSY CRDFWNILDG IVVTCALFAF GFAGTEGSAG KNLNTIKSLR
     VLRVLRPLKT IKRIPKLKAV FDCVVNSLKN VFNILIVYFL FQFIFAVIAV QLFNGKFFFC
     TDKNRKFAHT CHGQFFVYDN QNDPPRVEQR EWRLRPFNYD NTINAMLTLF VVTTGEGWPG
     IRQNSMDTTF EDQGPSPFFR VEVALFYVMF FIVFPFFFVN IFVALIIITF QEQGEAELSE
     GDLDKNQKQC IDFALNARPR SLFMPEDKNS TKYRIWRLVT SPPFEYFIMT MICCNTLILM
     MKYYNNPLFY EEILRLFNTA LTAVFTVESI LKILAFGVRN YFRDGWNRFD FVTVVGSITD
     ALVTEFGGHF VSLGFLRLFR AARLIRLLQQ GYTIRILLWT FVQSFKALPY VCLLIGMLFF
     IYAIVGMQVF GNIWLNAATE INRHNNFQSF FNAVILLFRC ATGEGWQDIM MAAVQGKDCA
     RAGSAEINFE KGQTCGSNVS YAYFTSFVFL SSFLMLNLFV AVIMDNFDYL TRDSSILGPH
     HLDEFIRVWA DYDPAATGRI HYTEMYEMLR IMAPPVGFGK KCPYRLAYKH LIRMNMPVAE
     DGTVHFTTTL FALIRESLSI KMRPVEEMDE ADEELRLTLK KIWPLKAKKN MVDLVVPPNH
     ELCFQKLTVG KIYAGLLILE NYRARKSGTE RQSNDSVPPS CYANDEMRCF TGSRKIPTSR
     RSVDKDCSEA VYDPWLPLPK RPNHNILLTL HNRPRR
//
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