ID A8WT82_CAEBR Unreviewed; 920 AA.
AC A8WT82;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN Name=Cbr-clh-2 {ECO:0000313|EMBL:CAP23693.2};
GN ORFNames=CBG02916 {ECO:0000313|WormBase:CBG02916a}, CBG_02916
GN {ECO:0000313|EMBL:CAP23693.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP23693.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP23693.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP23693.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; HE601438; CAP23693.2; -; Genomic_DNA.
DR AlphaFoldDB; A8WT82; -.
DR STRING; 6238.A8WT82; -.
DR WormBase; CBG02916a; CBP40876; WBGene00025876; -.
DR eggNOG; KOG0476; Eukaryota.
DR HOGENOM; CLU_006904_1_0_1; -.
DR InParanoid; A8WT82; -.
DR OMA; HGFKMEN; -.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IBA:GO_Central.
DR GO; GO:0006821; P:chloride transport; IBA:GO_Central.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720:SF15; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 2.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 144..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 303..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 350..370
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 391..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 461..482
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 526..551
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 563..582
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 625..689
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 41..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 706..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 920 AA; 101492 MW; 610588AD87A69166 CRC64;
MDPLAKVSIL SPLAMLQMHH HKPKKSWIRS VMSDVKRSLL DMSPGGKTDD ADEEPDDHIE
SNETFGEFCT RQAQNVVHFL VEDWFLSALL GIITAVLSVG MDVAIEVLQH GNLFFFEISA
LNIPISAHVT FYDKMLEIST YLAFSQWVAH IVILTMFSAI FCQIVSKQAV GSGIPEVKVI
MHGFKMENYL TTRTLVAKMV GLTLAMGGGL PIGKEGPFVH MGAIVATLLS KITSACQYSA
FFSNEGREME MLSSGCAVGI ACTFSAPIGG RQFPEGRFID HIRISAVLYA IESTSKYFAV
KNYWRGFLAA TCSAIVFRCA NFFVTAEQSG TITAFYQTRF PTDCFLVEEL PIFLLLGFIS
GLMGSLFIFI HRQISIFRSK NKVYKLIFRN NFLAFTVFMA FVVGVLTFPN GLGRYFAGRL
TFRETMADFF NNCTWVSNDS RRCPDSILTH WTGGTEGDVS IFTSLVLYYI LYFVLVAICI
SINVPAGVFV PSFIIGAAGG RLMGETMVVL FPEGMRGPGG PPIHPGLYAV VGAAAYTGAV
THTLSVSVII CELTGQLSPI LPVLVSVICA QTSNLFIAML MGNAVCKFLQ PSIYESIIRV
KKYPYLPDLP PSRVSVHTVK VEQLMVTDVI YITKDMTYRE MKDILQLAPH LRSFPIVTDH
ENKILLGSVA KRYLTMLLRR HVLVNQQDSR NIGRITPAEI FNTIRRTSMR LSRRSPSRRS
NSSQTRENSI PETARSDAVS NDQVEFVSER TISGNTLLSI SPLHCPNNIP LQAVFTRPSS
ADLSKAETNA DILLNRNIDL DEIAIDAAPF QLVLGSSLYK VHTLFSLLGL SHAYVTDCGK
LVGVVGLKEL RDAMANIYVR GAVAPVKPDR KLTSGTYLDM SQVHRDKLMN PPSTPPANGH
SINIESPKFG NSLTVPPMAL
//
