ID A8WUY8_CAEBR Unreviewed; 1247 AA.
AC A8WUY8;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 104.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=ptp-4 {ECO:0000313|WormBase:CBG03399};
GN ORFNames=CBG03399 {ECO:0000313|EMBL:CAP24299.2,
GN ECO:0000313|WormBase:CBG03399}, CBG_03399
GN {ECO:0000313|EMBL:CAP24299.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP24299.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP24299.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP24299.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE601244; CAP24299.2; -; Genomic_DNA.
DR AlphaFoldDB; A8WUY8; -.
DR STRING; 6238.A8WUY8; -.
DR WormBase; CBG03399; CBP44663; WBGene00026268; Cbr-ptp-4.
DR eggNOG; KOG4228; Eukaryota.
DR HOGENOM; CLU_007081_0_0_1; -.
DR InParanoid; A8WUY8; -.
DR OMA; FSDFWSM; -.
DR OrthoDB; 2903434at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF3; PROTEIN-TYROSINE-PHOSPHATASE; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1247
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002732073"
FT TRANSMEM 623..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 135..185
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 192..294
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 299..394
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 396..497
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..994
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 916..985
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1009..1241
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT REGION 733..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1247 AA; 142010 MW; BAE578C306DF9D3A CRC64;
MLRKHFIVFP FLLFWNHHLV ESLSVTSKNA TEALLRCPPA ESFIRTHMAP DFETPRLVRR
LDWFQDDSLV ASYQQGHVEG VEKELEKKKI GLDMPHISVD GHQNFHSFLN SWDKKKEKMV
SLNIGRLADS SRQWWVADGR YQLIRPFYTL RVSPVTPEDS GTYRCRLETD PLFSSPQSTA
TQELAVMVRP VAPSSPEIKS FTNRSITLVW THNAARAHRP ILRFSVSVRT VPFASYCPPS
IVNFRFVMAA PSNATTVIVD NLSPYTLYAF SVRAENSAGS SDFGPETTFR TLGEPPNRAP
QIQKIRNVTS ECVEVTVTPP DEMNGELEKY LVLIQAVNET NPRKMTFDKP TSTPLTICAL
TPSSEYALAI EADNGFGTSP QATLVFRTED SVPNWSPSTI KTTPVVGKPE IIVLWLAPPM
NATEKVVKYH LYYKANNEDQ WKIEHLNVNP NEVKSKMFKY RLVDLNPNTL YRIRVSASTS
KGEGSQSADS LAQTDVGEPG TVIFKDLNFD CKNGVKLSWN YEPSVNSKKS PTFTVKITNQ
TTSLQFNTTR QTLDIIDLSL YDEYSLRIIV LERSTIDNTT ILIGKYSDNH RFILKDKCAY
QSSFCSPGEK CAKLTSSAAN PQYISVLIVI FAIIIFAFIC FIIVHFARGS MNFKHLLKKK
EKCVYLEEIS PLVYGRLNRS DMISMKCYCL DSAGQEDIPV ELFYGYVEDL NRNDALKFKT
QFQILETQTS GIDQADSGES TSSADENSQK NRYNNIGAME ATRIRLNSPT GNDYINANYV
DSCNERNAYI ATQAPLPSTF SDFWSMIWQE RSNVIVCITN MVEDGKVKKG MSYFPNSIFR
FQRKCDQYWP SVPDSPQNFG NYQVTLISES TNAHFSHRVL DLKIAKSVPA AERKIHQLHF
VGWPDHGVPS SVFPLLNFIH YASDIHSTGP VVVHCSAGVG RSGSYILVDS MRRHLISFRR
LNVQGHLTHM RRQRAKLVQT LEQYIFCHEA IRQLIRHGIT RVHSDLFMRY LHYLSEENLN
GKTRMQLQYE DVCECKHQPR CLIDSDVLTL PGYHRSDEFM VGSWSHECEE LWKLIWKRKV
QTIVVLNQRD SFWRKLHLCE DIQLQHGDNF VLMQREDQQL CVRIMNVARS DLDADFWREI
ENVQKQRITY HDAPLLILAQ KFPPNASSPT DSTSTLSLSM LFNDDSSLAF SICAATTLAC
QLETTGCVDV VQVLSSYTEI QCGIFSSKQE IEIIYEKISQ LVEGTRV
//
