ID A8WXK1_CAEBR Unreviewed; 378 AA.
AC A8WXK1;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Protein CBR-NKB-2 {ECO:0000313|EMBL:CAP25139.1};
GN Name=nkb-2 {ECO:0000313|WormBase:CBG04440};
GN Synonyms=Cbr-nkb-2 {ECO:0000313|EMBL:CAP25139.1};
GN ORFNames=CBG04440 {ECO:0000313|WormBase:CBG04440}, CBG_04440
GN {ECO:0000313|EMBL:CAP25139.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP25139.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP25139.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP25139.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000256|ARBA:ARBA00005876}.
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DR EMBL; HE601251; CAP25139.1; -; Genomic_DNA.
DR RefSeq; XP_002634429.1; XM_002634383.1.
DR AlphaFoldDB; A8WXK1; -.
DR STRING; 6238.A8WXK1; -.
DR EnsemblMetazoa; CBG04440.1; CBG04440.1; WBGene00027108.
DR GeneID; 8576424; -.
DR KEGG; cbr:CBG_04440; -.
DR CTD; 8576424; -.
DR WormBase; CBG04440; CBP15066; WBGene00027108; Cbr-nkb-2.
DR eggNOG; KOG3927; Eukaryota.
DR HOGENOM; CLU_759165_0_0_1; -.
DR InParanoid; A8WXK1; -.
DR OMA; KGQPCIM; -.
DR OrthoDB; 2880589at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR PANTHER; PTHR11523:SF28; AT04468P-RELATED; 1.
DR PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..38
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 42077 MW; 0B8269E1DD480FE4 CRC64;
MIVSAKSGGD SEERKSFLDK PNSSKTANSA VSGVTEKSAK TEKSAKRSEQ KTDRSTKSGK
SATTTKTENG NQSMVSQKST ASTQSVGRQG PKMSDGTEFG SGPYGYIFSF IYLGVLWGLA
IILAIVLVYF NYSRLDPQFP TYFGDGSFLG GVPKATFDPN PRRFLEDGNL NVMEWNIYNF
DSYVNYLIRY KQLLKNYSGG DSVKKRVAGK NLCSNQTLTE AEACRFDRFT GFGECVLSHE
NLEHGFGFSK GQPCIMLKLN KIVGWAPNFE VNETQTCTPG NLCCGEGIQF ECKSDDDVQF
EFFPKTGIPS CYFPYMNQNG YEQPFQMVKL ANITFNRDTT IECYPKDNSL RTLASGKVNE
ARFHIKMSDE SVDEAKRS
//
