ID A8X178_CAEBR Unreviewed; 419 AA.
AC A8X178;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Protein CBR-AQP-3 {ECO:0000313|EMBL:CAP26388.1};
GN Name=aqp-3 {ECO:0000313|WormBase:CBG05966a};
GN Synonyms=Cbr-aqp-3 {ECO:0000313|EMBL:CAP26388.1};
GN ORFNames=CBG05966 {ECO:0000313|WormBase:CBG05966a}, CBG_05966
GN {ECO:0000313|EMBL:CAP26388.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP26388.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP26388.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP26388.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175, ECO:0000256|RuleBase:RU000477}.
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DR EMBL; HE600909; CAP26388.1; -; Genomic_DNA.
DR RefSeq; XP_002633245.1; XM_002633199.1.
DR AlphaFoldDB; A8X178; -.
DR STRING; 6238.A8X178; -.
DR EnsemblMetazoa; CBG05966a.1; CBG05966a.1; WBGene00028320.
DR GeneID; 8575242; -.
DR KEGG; cbr:CBG_05966; -.
DR CTD; 8575242; -.
DR WormBase; CBG05966a; CBP01652; WBGene00028320; Cbr-aqp-3.
DR eggNOG; KOG0224; Eukaryota.
DR HOGENOM; CLU_667712_0_0_1; -.
DR InParanoid; A8X178; -.
DR OMA; TWFWIPI; -.
DR OrthoDB; 2875289at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0015254; F:glycerol channel activity; IBA:GO_Central.
DR GO; GO:0015250; F:water channel activity; IBA:GO_Central.
DR GO; GO:0015793; P:glycerol transmembrane transport; IBA:GO_Central.
DR GO; GO:0006833; P:water transport; IBA:GO_Central.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR022357; MIP_CS.
DR PANTHER; PTHR43829; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR PANTHER; PTHR43829:SF29; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR PROSITE; PS00221; MIP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000477};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000477}.
FT TRANSMEM 118..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 35..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 374..401
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 419 AA; 46032 MW; 4D382CF5F4A44808 CRC64;
MLSDSSSDSS DRSFKFPFDT NDALSIHELA VKNLPQPDAE NPFSVAMHSP PGSPPFAVDR
KSVDNSVVAV TDTPFEFAPS QKSSQHTNRP PPILKSKEEK MTGNLVEKLK PKFVVENELI
RAFIAELFCT AFLVFGGECV NAQYVLSQGK NNEWIGVSVG WGIALMLAVL MGSKISGAHL
NPAVSFFQLT QGKMNVIRFL VYVVAQNIGA FIGAFGVFCV YFDAINAFEG GNRTVTGHTA
TASIFATYPG PFLGTFNAIV DQIAGTLVLC LGVAAITDSR NEIPSFLQPA WIAGLLSFLG
MSMALNAGYA INPARDFAPR LFSLCVGYGW EVFSYRNYKW FWIPIICPMI GGVLGAWIYE
FFIGYHIPDE TLLEAEKEKQ LQDVLDEVAD IENQLPEYTD KKQLSDIASI HQETGFRDI
//
