ID A8X2I0_CAEBR Unreviewed; 432 AA.
AC A8X2I0;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Protein CBR-NHR-256 {ECO:0000313|EMBL:CAP26840.2};
GN Name=nhr-256 {ECO:0000313|WormBase:CBG06550};
GN Synonyms=Cbr-nhr-256 {ECO:0000313|EMBL:CAP26840.2};
GN ORFNames=CBG06550 {ECO:0000313|WormBase:CBG06550}, CBG_06550
GN {ECO:0000313|EMBL:CAP26840.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP26840.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP26840.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP26840.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
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DR EMBL; HE601320; CAP26840.2; -; Genomic_DNA.
DR AlphaFoldDB; A8X2I0; -.
DR STRING; 6238.A8X2I0; -.
DR EnsemblMetazoa; CBG06550.1; CBG06550.1; WBGene00028810.
DR WormBase; CBG06550; CBP26220; WBGene00028810; Cbr-nhr-256.
DR eggNOG; KOG3575; Eukaryota.
DR HOGENOM; CLU_007368_17_0_1; -.
DR InParanoid; A8X2I0; -.
DR OMA; MIRRQWK; -.
DR OrthoDB; 2879737at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46397:SF5; NR LBD DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR46397; NUCLEAR HORMONE RECEPTOR FAMILY-RELATED; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 2..78
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 182..432
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 78..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 50337 MW; CB39B144F2238560 CRC64;
MSRNCKICDS PNATNLHFGA HACKACAAFF RRTVRGNLAY KCSSTNNCEI YHAFRQNCRQ
CRLTKCFRAG MKEEIVQGFK RSPENQSHKR TMDEQQPTTS NYYDSNPPAP YWDDSPPTKI
LRDDVEIMEM HELQEYIQIP NHLDNTVLLV PISPPLDPRI DEDERLYSLA SLYMEKFVSL
NMRRRLTYAN VSLAAMFDVP CVCPFEKSDL LPFDHRSYRF KNRNDYTMIL DYVNQFPDFH
MLNKSEKTVL FQTAAAVDAL ADPAYYSQVI FPNEAFFVTR EAKFVRMDPL PSLELDTSTE
DYSKEDVTMY RSMISMIRRQ WKNVNVPLGQ LKMSISEFSL FKALTIWHYN YYKLQDSGKA
ISARQRDDIF RTLLLICTDE GHEDPMLRVS EIVLAVGNVM TEVHELVTTL LEITVFDEVQ
DPILKDMLKF KY
//
