ID A8X2J9_CAEBR Unreviewed; 500 AA.
AC A8X2J9;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Solute carrier family 40 member {ECO:0000256|RuleBase:RU365065};
GN Name=fpn-1.2 {ECO:0000313|WormBase:CBG06568};
GN ORFNames=CBG06568 {ECO:0000313|EMBL:CAP26859.1,
GN ECO:0000313|WormBase:CBG06568}, CBG_06568
GN {ECO:0000313|EMBL:CAP26859.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP26859.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP26859.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP26859.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: May be involved in iron transport and iron homeostasis.
CC {ECO:0000256|RuleBase:RU365065}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU365065}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU365065}.
CC -!- SIMILARITY: Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A
CC subfamily. {ECO:0000256|ARBA:ARBA00006279,
CC ECO:0000256|RuleBase:RU365065}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365065}.
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DR EMBL; HE601320; CAP26859.1; -; Genomic_DNA.
DR RefSeq; XP_002647495.1; XM_002647449.1.
DR AlphaFoldDB; A8X2J9; -.
DR STRING; 6238.A8X2J9; -.
DR EnsemblMetazoa; CBG06568.1; CBG06568.1; WBGene00028826.
DR GeneID; 8589494; -.
DR KEGG; cbr:CBG_06568; -.
DR CTD; 8589494; -.
DR WormBase; CBG06568; CBP15709; WBGene00028826; Cbr-fpn-1.2.
DR eggNOG; KOG2601; Eukaryota.
DR HOGENOM; CLU_020370_4_0_1; -.
DR InParanoid; A8X2J9; -.
DR OMA; YPVFISY; -.
DR OrthoDB; 38357at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009716; Ferroportin-1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11660; SOLUTE CARRIER FAMILY 40 MEMBER; 1.
DR PANTHER; PTHR11660:SF69; SOLUTE CARRIER FAMILY 40 PROTEIN; 1.
DR Pfam; PF06963; FPN1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU365065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365065};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365065};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365065};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365065}.
FT TRANSMEM 80..99
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 164..182
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 282..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 312..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
FT TRANSMEM 449..473
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365065"
SQ SEQUENCE 500 AA; 55208 MW; C71685ABC1BB502E CRC64;
MTFQSPQNKS SLSKASIFLY CAYISTCLED RAWSFCVSLC MDLLGGMRVV SIEQLFEGVL
QMVLSGYLGK HFDGLSRKRA IMTVVPLNNL SICAAAALII TCLSMDTTSP WYIVCLVVAM
CMCAVNRLFL NSEKFITGRD WVMVLGNDGT LSSMNATLLT LDQFTNVIAP LVTGALVTWV
GLRETVGIFG IASLLSMTSK SIFLRMIYIS NPLLQVKKDK KEYIDPFANS RLKESVVYTY
WRQVSFPAAF GMSLLFMTVM GFDGLAVGYG TSAGLPEFVV GAFRSYGSAT AILGAFSYAF
FEKQYSVATS GLLGLGVQQL FAILAVISVF LPGSPMNLDG YFGNFTVGTW WHDLVHSFNG
NNATNLDPHV DWKHFSSDGV SLASIFVFLI AIASARYGLW CLDLAITHIM QVTIPERERN
TVFGMHNALC QTFSVLKDVL VIILPLPATF AICIFISYGF VTAGHAFFLY YLVKTNSLST
IGRRLSQIEE KEEKEEFARL
//
