ID A8X8K7_CAEBR Unreviewed; 581 AA.
AC A8X8K7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Protein CBG09644 {ECO:0000313|EMBL:CAP28968.2};
GN Name=del-6 {ECO:0000313|WormBase:CBG09644};
GN ORFNames=CBG09644 {ECO:0000313|EMBL:CAP28968.2,
GN ECO:0000313|WormBase:CBG09644}, CBG_09644
GN {ECO:0000313|EMBL:CAP28968.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP28968.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP28968.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP28968.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
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DR EMBL; HE600998; CAP28968.2; -; Genomic_DNA.
DR RefSeq; XP_002637142.1; XM_002637096.1.
DR AlphaFoldDB; A8X8K7; -.
DR STRING; 6238.A8X8K7; -.
DR EnsemblMetazoa; CBG09644.1; CBG09644.1; WBGene00031202.
DR GeneID; 8579138; -.
DR WormBase; CBG09644; CBP34427; WBGene00031202; Cbr-del-6.
DR eggNOG; ENOG502SIAB; Eukaryota.
DR HOGENOM; CLU_531272_0_0_1; -.
DR InParanoid; A8X8K7; -.
DR OMA; ISQMQIC; -.
DR OrthoDB; 2873667at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF227; DEGENERIN LIKE; 1.
DR Pfam; PF00858; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 581 AA; 67086 MW; B953BC884CC5B48C CRC64;
MGAKVKDQTS VEMHDVNEPR HAHPEDDKPS SWKDALFGRR ARKYAFIFIV AFLAVLTVKD
VFDLFEEYFE YPKESDINIV FNESMTMPNV TFCMSRAQAW SHFKLNLSAP ADEWDAVVDE
SLANMTDHDA FMKQPWDYRL VMEAYDMIAT YSSLERETTA HGSARSIHVF KNSPRLAAKR
KTFKKWRDIL DSRRITFDEF TQKTGIEVLR RSMQRFRRRT FDDDDTVIKT KLRISWISQM
QICYQPEFDK DNFKTIDDQG VFFDMLLSHN AENTEGQKID CMSVDFHGRP SSLNRFMEGK
GRSRDGFIDE LCLGQRHEVT AHVTALYQML ENDEEGTRCR DVEDGEDSEF NCRSRCRMEM
IRDACHCTPL SLSYLAKKED MEIFPLCDYT QCTVDVQKGN YSDTECANKC FPDCRQIRFE
VDHSVKGRML RPDLTLVELS WGPFEYLTME QQWKYTPTTF IAALGGSIGM WLGLSILSLI
QLVTYSYTYF TKKIVNEKIL KKGNTFDRRD GEDEDGDFTI DNGTERKKMS LAENPFAEFF
PGGSPEQPKK GGSKPNSRQA SLDKEGGNSQ GYSANPKGTR S
//
