ID A8X8R7_CAEBR Unreviewed; 1104 AA.
AC A8X8R7;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=Cbr-gcy-6 {ECO:0000313|EMBL:CAP29028.2};
GN ORFNames=CBG09580 {ECO:0000313|WormBase:CBG09580}, CBG_09580
GN {ECO:0000313|EMBL:CAP29028.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP29028.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP29028.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP29028.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; HE600998; CAP29028.2; -; Genomic_DNA.
DR AlphaFoldDB; A8X8R7; -.
DR STRING; 6238.A8X8R7; -.
DR WormBase; CBG09580; CBP40393; WBGene00031141; -.
DR eggNOG; KOG1023; Eukaryota.
DR HOGENOM; CLU_001072_1_3_1; -.
DR InParanoid; A8X8R7; -.
DR OMA; GFLHCDV; -.
DR OrthoDB; 2877804at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06352; PBP1_NPR_GC-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF76; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-6; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1104
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002730219"
FT TRANSMEM 484..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 558..850
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 908..1038
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1104 AA; 124715 MW; 6422F4DFB598367A CRC64;
MHPTTAVLLF LATVDCQPPG NIFHLGFLHC DVLQKNVEGS SPYISYRTSA SAASIAIDRI
KRENRLTGYD FKFTILYDQC DENLAAGNAI KLFRDYNYCF ISAAIPVFTL ATYYNTPIVT
WGMTSSATLD DASRYPTAGI ISIGSRRHRY FSLAVTFREV MLEYGWDQFV YAYSLEGDDE
KCETMRDDFQ NMIAYYGDIV LSYTIQIMDH SEAGLLAVLK DVSTRGRIIV PCFHEGNTRG
LHRRWMLVAA RNGFVTDEYV YIIPSLRSKG YAIQQDDGSY RYPWVDSTGP QPSDHEAIPG
FQRSIFIVDM QGQGKIGSNY SVFEDEVIRR MKQPPYNCTE ACSAQEYQHA ATYAGQLHDA
VYLYGLAMER VLITAPTQYR NGTQFGFLEN IFSGHHNLGV GGPIVIDDSG GRSPTLFVLT
LDANNTSSII MTVDVDQQSA EVTKLYSNEA TAVWYHRKGI RPPDEPVCGY TGSKCPANVF
YENMGWFIAA IIVILLTILG AILAFVYLFY AKRQEVERQN ALWQIPYKSM MTVAKKGKGE
HSMRSISSVP STISSTRSST LSEVGETRNY LFFQIQNEVE IEKVAARKYT IRTLFDNKIC
ANMRQMRLID HSNLNKFIGM SLDAPQLLSV WRFCSRGSLA DVIRKASLQM DGFFIYSLMK
DIVNGLTWIH DSSHEYHGML TSKNCLLNDR WQLKITDFGL RNFRTHDQYT KMGELLEILY
FSEVFKFSDR LWTAPELLRN DDIMGSREGD VYSLGIISAE LITRSSVFDL ENRKEDAEEI
VYMLKKGGLQ SPRPHLDHDE SIEINPGLLH LVRDCWTERP SERPDIKQVA SQLRSMNTNR
NDNLMDHVFN VLESYASTLE DEVAERMKEL VEEKKKSDVL LYRMLPKQVA DKLKLGQTVE
PETFDVVTLF FSDVVSFTTL AGKCTPLQVV NLLNGLYTIF DGIIEQHDVY KVETIGDGYF
VASGVPRRNG NEHTRNIASM SLCFVKSLAD FNIPHLPGEK INIRVGFHCG SVVAGVVGLT
MPRYCLFGDA VNTASRMESN SKPSCSNFSA GHVHISDEAN RMLMTLGGFT TETRGEVIIK
GKGVMTTYWL LKMDESAAPK NLKK
//