ID A8X944_CAEBR Unreviewed; 3304 AA.
AC A8X944;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 16-DEC-2008, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Protein CBR-DHC-3 {ECO:0000313|EMBL:CAP29156.2};
GN Name=dhc-3 {ECO:0000313|WormBase:CBG09431};
GN Synonyms=Cbr-dhc-3 {ECO:0000313|EMBL:CAP29156.2};
GN ORFNames=CBG09431 {ECO:0000313|WormBase:CBG09431}, CBG_09431
GN {ECO:0000313|EMBL:CAP29156.2};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP29156.2, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP29156.2, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP29156.2,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
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DR EMBL; HE600954; CAP29156.2; -; Genomic_DNA.
DR STRING; 6238.A8X944; -.
DR WormBase; CBG09431; CBP49703; WBGene00031013; Cbr-dhc-3.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_225199_0_0_1; -.
DR InParanoid; A8X944; -.
DR OMA; EPANCKS; -.
DR OrthoDB; 3615570at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0030286; C:dynein complex; IBA:GO_Central.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR PANTHER; PTHR10676:SF242; DYNEIN, AXONEMAL, HEAVY CHAIN 3, ISOFORM D; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF12777; MT; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549}.
FT DOMAIN 628..993
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 2169..2439
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT REGION 1362..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2116..2146
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2387..2435
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3304 AA; 383918 MW; D73B3710D423BF0F CRC64;
MYEIGFGNIY HPKCHGLTCR DIPRDLDYSN RKLVHHNNQG KRIRKQNGRL TFHRGIEIDG
KKIKRPREAS SIRKKIKTTH TDFKTEDVLH EECLPSFPAW KGQIESLSEK LKEGGLETTI
RELSTNWKDW TRDAANAYLK GDNVRIPCIG RAPWRHTMAQ NTEKICNQLR LNNKIITMFF
KKYRDRCLID CSFLLSENGR SVPELEKQLK DFVVYTKKIL SFEWPMAVAN LMLDEGASWI
PLFVTAQSHT VFNAVAATMA RLLYDVVLEN ITRIKTFFDI DDRAKLIIIL NEDEKEFDYW
QRINILLDLC KIPRVDHKIY PRMFTEAWID VRNWFDSESI VFKPLPQPFE LLNSRISEVQ
EMLVSFSKDP DDVAFWERIA KEILDIREQV LKQGTRVLKG FTIYDSRDIK KRSLAKITES
EERLKHIILT RLIVKNTKIR ELFTLCSGKL FRNDVLVQLR NIEEVQNELP NIKVKIQCVG
KAYKFYEISR LGFKLDQLVN FVWDRINHER QWITKQVSDQ TSKNYYECEM IEKEWLDCLK
KYRSAVRINE VQKVQIKMGN LEERSAILKG KDEKLIGQRS LLGLPSSPID CIRIAKVCAF
FSKLSTLHFK TLLHHESCLR MRISDVDHNF LVAETERLQS EKDNLMEAAT AINEHATTSK
EALLKIQNVL VEFEKLLPVL GAISCQAMKD RHWKMILQDS ETSVKVEGNP LVSELLEMNF
IEKADKFEQV GAQAEKERVL ETSIDKMRSQ WKSATFMTHQ GGELLTTELN VQMQAHLARS
QTILSSPHAF SILDHIRHWL DTLLNLNNFV HLYKRCDLRW KKIEGVFSTE DIAYQMPHEF
RTFKKISLRW LHINNQITEE RPILEQMDLV QQLNIDLSEL EVLFGRMENG FHAYLRKKRA
VFPRLFSLSD ELVLSLICDS REPANCKSYI PLLFPSLVTF DQNTKMEIVS VSTKHETISL
VKPVNVNLSK RHVEKWMHEL DAQIKYTLRT RIRLLIEKMN YKLSPVESIL SEPIQVASVY
LKIAFTWQME NSMKQNSMTV RKMKILDADF KVSDSRKVSA GFISHLQVRC VYNRRSLQSL
FLPANHLVNK FINEQVIFID DYRWISQLRY YWHMENVFIR VGTVSTRYDY EVQGIDYMVD
NRLIDESVKH FIYMNHFGFN GKVHGIDANS ARQISGALGK PFAICDTDQE MDCKMLIEGS
LLFGGTVFIE ENSCEDLGKS TEKDVYSSHC LLNLKYHFES EITLNASFIF LLSSQALQTA
RRLQLGSNSY LKLIDEILSL NSIAHREKKV QKFQVITELE SYTRAENLWR NYTESMITKI
LENEDLEQEQ VIENSIFRCL SISLNKKNKK LLESLLNISL NPKPKKSPTP AKTPKSSDVP
RKMLDTDPLP IREKIEDLVN LLQNHQVVVV YGGSQTGKSR VIAKAAKLKS ADLEVQFGLW
EDIKPFGESL KNMRRPNKWI VIDGFMSSKT RQWIHRLMNE NTVISLESQL FPWRELPIIA
SSERVIIETD CLTDDLKSLP LVFLNNNDAF IKETMLDQTE QQRLDDVLNY YSEFKYRKLE
LIRKIEGLKK QIITNSEKVF EHILIMSLLT FVPATQLMSF FFKSNEKLLE FYSNVPYSDG
WYTYKEGMDI SPSHFYLIHS ISMILYSEFI PLLICPPSQE FYEFLSRLQA ELDALGWHTI
TMCIDEKVTI EEIKQFVDNC AIMFGGHQHQ EKDFDDPQEG SNFFLIRGIE NAPSEVIDWL
RHQYERKHIM KTLFVTSYSV ETFHKRIQRF LFPINWMDIT GEQSLTLFPL SNYSSVLKNI
TKDIKIKEIS DSIQNNLIGA MLDARILSLY EKVFELKTSE RYDLVRGKTY IEVGELCSIY
LNATKELVER NKRIRCDNVI LSPTDAENIN IIEKVNQTNY GHVVVVGNDT SKALEALMVS
TELSRHMLYT NQGIKTKEEW GDLMNRVLRD SLIDGKETVL GLTVSPDEEI AETILVDMKC
ICGYKLIPPR YLSRLMLSEF GEKHTLEGKG IWEMLETKLS ALKVSLILKS SDFSWFMNCH
RMLLSMMILV WWGDPSRKEQ EQEILDELHN SGLFSKQQTE QLMKVIDELI SMKILNTRAE
KLKMISTITK LAKKKKEEVR KTMTKYEKGM EKMKRAEEQV AGMQGELLRL QPQLVRTSIE
TSLKSNFSML MSTIEKETID VENAREVVAA NENKSNEAAT KAQSLKAESE AELTSAIPAL
ESAVEALETM TQSDVSSLKT MRFPPYAVRL CMEAVCILLG VKPAKITNEI GEVVNDYWVS
GQKLLSDIHF LAKIRSFARD SMSKKTMKLI RDKYLSKEEF DPDKVKQCSL AAEGLCRWVL
AIDMYNQISK IVEPKRERLR KAEVLVKQHL KQLEVKRKAL LKVTEKLQGL SDQFSQMCQK
KQELESQISS CEVRMERAER LVQALSGEKD KWKSKITDVT HEDSLSVPYS VGSALALHIF
GKLPIDQREK ELRKTMRSLF PKLEITIACD LKTLVMLVDD PICFINDDSR ALEFLESKFE
KVVVSNQWSE AERQQCLASN SVLLFEINQE NLKAAEEIDN AEYYSQMEEE IVIKIGNHQH
EVNKNFRVFF RTRGANNLNL KKSVIIDNQF SDGELRHDIC EMMGSANWAE TLNHYNEMVE
SRNNDIAMME KTENEMLDLL GRSKDLDDER AIDLLAEARN LQSSIVARNK EIAEIETSLR
SIESKMSQCI DYSMKVIKMS YTLHLLDPFY RISLSDLVNV LETKLFDNIS DINHDKINHQ
ISDLYWNFLC HMLACDDKMI VHHLLFHKMN YQVLEMEMKN RITMDSFFNF SAFILKSEPK
QLILMKYDAE VYTTILQFGQ VTRNANWRCF SILDHVLLRL EKLVDEPIWL LLNVNRSCQT
TVRKLKSVLD KLKNLPVVHS SFRIIIGYSN EIECSEEMIA LSSHRFYFSA SAYLFQQTRR
ILANLSIRSS LDKSEEKQRI QIIRLMCFHY GLKLRRKYNP ELSFKVDDAD LLAMMKLYQE
LRNLSDQPNE IQDVMKVKTC VIEPIYYPKT NCPVEKNIIS SMIQWIVEVN LSIPADTLLK
NIIREDNHNF VGEQITIKKE LINFQEDFSH FMQSHDESIL CGYNARISRE SRLLMEKKVV
QKMKVLFDEN QETPGDCIKN NEKLRTRSFM ADVENGNREL DGRKVVNITE LISYLKMQFC
LKYKIGIAEV MMNAEFVNDN YELPKIGSES DVPMLKLSHC ILESAHFIQG EIRELHNHQS
QHVTVLLKTS KRTGASNPRS LPLICPSTRM SVAQIPFHSQ FPIAHWHLRG VYVTAGKTER
GIRS
//
