ID A8X996_CAEBR Unreviewed; 639 AA.
AC A8X996;
DT 15-JAN-2008, integrated into UniProtKB/TrEMBL.
DT 15-JAN-2008, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Protein CBG09364 {ECO:0000313|EMBL:CAP29208.1};
GN ORFNames=CBG09364 {ECO:0000313|EMBL:CAP29208.1,
GN ECO:0000313|WormBase:CBG09364}, CBG_09364
GN {ECO:0000313|EMBL:CAP29208.1};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238 {ECO:0000313|EMBL:CAP29208.1, ECO:0000313|Proteomes:UP000008549};
RN [1] {ECO:0000313|EMBL:CAP29208.1, ECO:0000313|Proteomes:UP000008549}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16 {ECO:0000313|EMBL:CAP29208.1,
RC ECO:0000313|Proteomes:UP000008549};
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
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DR EMBL; HE600954; CAP29208.1; -; Genomic_DNA.
DR RefSeq; XP_002636902.1; XM_002636856.1.
DR AlphaFoldDB; A8X996; -.
DR STRING; 6238.A8X996; -.
DR GeneID; 8578897; -.
DR KEGG; cbr:CBG_09364; -.
DR CTD; 8578897; -.
DR WormBase; CBG09364; CBP40399; WBGene00030962; -.
DR eggNOG; KOG3270; Eukaryota.
DR HOGENOM; CLU_428445_0_0_1; -.
DR InParanoid; A8X996; -.
DR OMA; DEMEYCS; -.
DR OrthoDB; 2880044at2759; -.
DR Proteomes; UP000008549; Unassembled WGS sequence.
DR GO; GO:0000813; C:ESCRT I complex; IBA:GO_Central.
DR GO; GO:0006612; P:protein targeting to membrane; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IBA:GO_Central.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678:SF27; LD45836P; 1.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR Pfam; PF07200; Mod_r; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000008549};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 504..593
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
SQ SEQUENCE 639 AA; 70482 MW; 55EC1B2D5666B9BE CRC64;
MLFKSSSSDI RSISSLTPLP NRPFLTVSDG GKLTCNFDDE MEYCSWHNAE NTDMKFWKGK
LDSESRFDPS RFNSGSSLSF SPDNNFLLAG GEPMVASQTA AIEMEIPCQY GDADVKLDFW
TNNLNVDVRY CIAKSGSDFH DCHLLQRVSN PLNFSVPTTA DGLKVRIEVL NIDPDSIALV
DNLHYNGQIC ELIDEVVENS LVPIGDTTSS TPPLITGNPP LPTDPTVQKF FEEDSNGIEE
SETPSSIGIQ AVTSTAVSTA VSSQVNVKEL SFCSALTCSF NDGDSCFYGL SGVGSTEAWS
LSDRLIGNRH TGIQRVNLDD QSKVGFAYVG NDTVSQEQKI FVAESPKFSL IQDTLLLFDI
YIRSVSPTLR VCIDLFDNCP YKSPMVRKDK FWRGRQKVAL KEGSRKLKMF NQSPYESHVD
IAVSAASANL RNMSNEQLMA LLDDEALLES IIVNLPQVRS IPTDKESALA ANKSLAEWNL
AQKPRIDAAK SQTINLYEQV KRLQGEVTVL KNQLDSISSS KSLDTTSSLM QVAAQEADED
AESLFTQFEN GDVTIDIFLK HFKEKKTVAH LRKIKSDRLT ALLREQTYSY AQPTVPPPMP
QPGYPTGNHM PGLGKIPFGS GYTGYPNVSQ PSAGRHPFF
//
